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http://hdl.handle.net/10397/87586
Title: | Current advances in skin-on-a-chip models for drug testing | Authors: | Zhang, Q Sito, L Mao, M He, J Zhang, YS Zhao, X |
Issue Date: | Aug-2018 | Source: | Microphysiological systems, Aug. 2018, v. 2, 4, p. 1-9 | Abstract: | Skin-on-a-chip models are highly desirable in drug testing compared to conventional 2D cell culture and animal models as they can replicate organ-specific 3D structural organization and physiological functions at a relatively low cost. To engineer a physiologically relevant skin model, human skin structures have been integrated onto microfluidic platforms to construct skin-on-a-chip systems that can mimic the complex in vivo situation. In this mini-review, we first briefly introduce some critical technologies employed to develop in vitro skin-on-a-chip models. We then review the applications of the state-of-the-art skin-on-a-chip models in drug testing, with a focus on using models of full-thickness skin equivalents (FTSEs), skin models with additional components such as vasculature, immune cells and hair follicles as well as multi-organ-on-a-chip models. Finally, we discuss some current challenges and future directions of development of complex, and in vivo-like skin-on-a-chip models. | Keywords: | Organ-on-a-chip Human skin equivalents (HSEs) Skin-on-a-chip Microfluidics Drug testing |
Publisher: | AME Publishing Company | Journal: | Microphysiological systems | EISSN: | 2616-275X | Rights: | © Microphysiological Systems. All rights reserved. Microphysiological Systems is a peer reviewed, open access journal. All content of the journal is published under the Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International License (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/). All articles published open access will be immediately and permanently free for all to read, download, copy and distribute as defined by the applied license. The following publication Zhang Q, Sito L, Mao M, He J, Zhang YS, Zhao X. Current advances in skin-on-a-chip models for drug testing. Microphysiol Syst 2018;2:4 is available at http://mps.amegroups.com/article/view/4737 |
Appears in Collections: | Journal/Magazine Article |
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Zhang_Skin-on-a-chip_Models_Drug.pdf | 5.14 MB | Adobe PDF | View/Open |
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