Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87586
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Zhang, Q | en_US |
dc.creator | Sito, L | en_US |
dc.creator | Mao, M | en_US |
dc.creator | He, J | en_US |
dc.creator | Zhang, YS | en_US |
dc.creator | Zhao, X | en_US |
dc.date.accessioned | 2020-07-16T03:59:09Z | - |
dc.date.available | 2020-07-16T03:59:09Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87586 | - |
dc.language.iso | en | en_US |
dc.publisher | AME Publishing Company | en_US |
dc.rights | © Microphysiological Systems. All rights reserved. | en_US |
dc.rights | Microphysiological Systems is a peer reviewed, open access journal. All content of the journal is published under the Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International License (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/). All articles published open access will be immediately and permanently free for all to read, download, copy and distribute as defined by the applied license. | en_US |
dc.rights | The following publication Zhang Q, Sito L, Mao M, He J, Zhang YS, Zhao X. Current advances in skin-on-a-chip models for drug testing. Microphysiol Syst 2018;2:4 is available at http://mps.amegroups.com/article/view/4737 | en_US |
dc.subject | Organ-on-a-chip | en_US |
dc.subject | Human skin equivalents (HSEs) | en_US |
dc.subject | Skin-on-a-chip | en_US |
dc.subject | Microfluidics | en_US |
dc.subject | Drug testing | en_US |
dc.title | Current advances in skin-on-a-chip models for drug testing | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 9 | en_US |
dc.identifier.volume | 2 | en_US |
dcterms.abstract | Skin-on-a-chip models are highly desirable in drug testing compared to conventional 2D cell culture and animal models as they can replicate organ-specific 3D structural organization and physiological functions at a relatively low cost. To engineer a physiologically relevant skin model, human skin structures have been integrated onto microfluidic platforms to construct skin-on-a-chip systems that can mimic the complex in vivo situation. In this mini-review, we first briefly introduce some critical technologies employed to develop in vitro skin-on-a-chip models. We then review the applications of the state-of-the-art skin-on-a-chip models in drug testing, with a focus on using models of full-thickness skin equivalents (FTSEs), skin models with additional components such as vasculature, immune cells and hair follicles as well as multi-organ-on-a-chip models. Finally, we discuss some current challenges and future directions of development of complex, and in vivo-like skin-on-a-chip models. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Microphysiological systems, Aug. 2018, v. 2, 4, p. 1-9 | en_US |
dcterms.isPartOf | Microphysiological systems | en_US |
dcterms.issued | 2018-08 | - |
dc.identifier.eissn | 2616-275X | en_US |
dc.identifier.artn | 4 | en_US |
dc.identifier.rosgroupid | 2018003551 | - |
dc.description.ros | 2018-2019 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 202007 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0596-n36, OA_Others (ROS1819) | en_US |
dc.identifier.SubFormID | 480 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | P0006214 | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Zhang_Skin-on-a-chip_Models_Drug.pdf | 5.14 MB | Adobe PDF | View/Open |
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