Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82261
Title: SARI prevents ocular angiogenesis and inflammation in mice
Authors: Zhang, WQ
Dai, L
Li, X
Li, YM
Yap, MKH 
Liu, LQ
Deng, HX
Issue Date: 2020
Source: Journal of cellular and molecular medicine, Apr. 2020, v. 24, no. 7, p. 4341-4349
Abstract: SARI (Suppressor of AP-1, regulated by IFN-beta) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin-induced uveitis (EIU) and experimental argon laser-induced choroidal neovascularization (CNV) model in SARI wild-type (SARI(WT)) and SARI-deficient (SARI(-/-)) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF-positive cells were presented in the retina of SARI(-/-) mice with CNV. Compared to SARI(WT) mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI(-/-) mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization.
Keywords: Age-related macular degeneration
Choroidal neovascularization
Regulated by IFN-beta
Suppressor of AP-1
Uveitis
Vascular endothelial growth factor
Publisher: Wiley-Blackwell
Journal: Journal of cellular and molecular medicine 
ISSN: 1582-1838
EISSN: 1582-4934
DOI: 10.1111/jcmm.15096
Rights: © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
The following publication Zhang, W. Q., Dai, L., Li, X., Li, Y. M., Yap, M. K. H., Liu, L. Q., & Deng, H. X. (2020). SARI prevents ocular angiogenesis and inflammation in mice. Journal of Cellular and Molecular Medicine, 24(7), 4341-4349. is available at https://dx.doi.org/10.1111/jcmm.15096
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