Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/82261
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | - |
dc.creator | Zhang, WQ | - |
dc.creator | Dai, L | - |
dc.creator | Li, X | - |
dc.creator | Li, YM | - |
dc.creator | Yap, MKH | - |
dc.creator | Liu, LQ | - |
dc.creator | Deng, HX | - |
dc.date.accessioned | 2020-05-05T05:59:19Z | - |
dc.date.available | 2020-05-05T05:59:19Z | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | http://hdl.handle.net/10397/82261 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Zhang, W. Q., Dai, L., Li, X., Li, Y. M., Yap, M. K. H., Liu, L. Q., & Deng, H. X. (2020). SARI prevents ocular angiogenesis and inflammation in mice. Journal of Cellular and Molecular Medicine, 24(7), 4341-4349. is available at https://dx.doi.org/10.1111/jcmm.15096 | en_US |
dc.subject | Age-related macular degeneration | en_US |
dc.subject | Choroidal neovascularization | en_US |
dc.subject | Regulated by IFN-beta | en_US |
dc.subject | Suppressor of AP-1 | en_US |
dc.subject | Uveitis | en_US |
dc.subject | Vascular endothelial growth factor | en_US |
dc.title | SARI prevents ocular angiogenesis and inflammation in mice | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 4341 | - |
dc.identifier.epage | 4349 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 7 | - |
dc.identifier.doi | 10.1111/jcmm.15096 | - |
dcterms.abstract | SARI (Suppressor of AP-1, regulated by IFN-beta) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin-induced uveitis (EIU) and experimental argon laser-induced choroidal neovascularization (CNV) model in SARI wild-type (SARI(WT)) and SARI-deficient (SARI(-/-)) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF-positive cells were presented in the retina of SARI(-/-) mice with CNV. Compared to SARI(WT) mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI(-/-) mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of cellular and molecular medicine, Apr. 2020, v. 24, no. 7, p. 4341-4349 | - |
dcterms.isPartOf | Journal of cellular and molecular medicine | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000517360200001 | - |
dc.identifier.scopus | 2-s2.0-85081012310 | - |
dc.identifier.pmid | 32119762 | - |
dc.identifier.eissn | 1582-4934 | - |
dc.description.validate | 202006 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Zhang_SARI_Prevents_Ocular.pdf | 1.65 MB | Adobe PDF | View/Open |
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