Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80466
Title: An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model
Authors: Yue, GGL
Lee, JKM
Chan, BL
Kwok, HF
Hoi, SWH
Sze, DMY 
Fung, KP
Leung, PC
Lau, CBS
Keywords: Metastatic breast cancer
Chinese herbal medicines
Metastasis
Andrographis paniculata
Acanthopanax senticosus
Camellia sinensis
Hedyotis diffusa
Issue Date: 2018
Publisher: BioMed Central
Source: Chinese medicine, 22 Dec. 2018, v. 13, 64, p. 1-12 How to cite?
Journal: Chinese medicine 
Abstract: Background: The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. However, most of these herbal formulae/products lack of evidence-based efficacy. Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely Andrographis paniculata, Acanthopanax senticosus, Camellia sinensis, and Hedyotis diffusa were eventually selected to form an innovative herbal formula.
Methods: The anti-tumor efficacies of the formula were evaluated in metastatic breast cancer mice model. The bone protective and immunomodulatory effects were also assessed after formula treatment.
Results: Our results showed that the breast tumor weight as well as lung and liver metastasis in mice could be reduced after herbal formula treatment for 4weeks. The breast tumor-induced osteolysis in mice was restored by herbal formula treatment, in which the bone volume in treated mice tibia was comparable to that in the non-tumor bearing normal mice. The IL-12 level was augmented and the survival of mice with metastatic breast tumors was prolonged after treatment. Furthermore, combination of herbal formula with chemotherapeutic agent doxorubicin resulted in better anti-tumor efficacy and increased life span in tumor-bearing mice, when compared with doxorubicin alone treatment.
Conclusions: In summary, our innovative Chinese herbal formula was demonstrated to possess anti-tumor, anti-metastatic and bone-protective activities in metastatic breast tumor-bearing mice. The preclinical data generated in this study would lead to the development of evidence-based supplement as adjuvant therapy for metastatic breast cancer.
URI: http://hdl.handle.net/10397/80466
EISSN: 1749-8546
DOI: 10.1186/s13020-018-0222-9
Rights: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise state.
The following publication Yue, G. G. L., Lee, J. K. M., Chan, B. L., Kwok, H. F., Hoi, S. W. H., Sze, D. M. Y., . . . Lau, C. B. S. (2018). An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model. Chinese Medicine, 13, 64, 1-12 is available at https://dx.doi.org/10.1186/s13020-018-0222-9
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