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dc.contributor.authorYue, GGLen_US
dc.contributor.authorLee, JKMen_US
dc.contributor.authorChan, BLen_US
dc.contributor.authorKwok, HFen_US
dc.contributor.authorHoi, SWHen_US
dc.contributor.authorSze, DMYen_US
dc.contributor.authorFung, KPen_US
dc.contributor.authorLeung, PCen_US
dc.contributor.authorLau, CBSen_US
dc.identifier.citationChinese medicine, 22 Dec. 2018, v. 13, 64, p. 1-12en_US
dc.description.abstractBackground: The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. However, most of these herbal formulae/products lack of evidence-based efficacy. Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely Andrographis paniculata, Acanthopanax senticosus, Camellia sinensis, and Hedyotis diffusa were eventually selected to form an innovative herbal formula.en_US
dc.description.abstractMethods: The anti-tumor efficacies of the formula were evaluated in metastatic breast cancer mice model. The bone protective and immunomodulatory effects were also assessed after formula treatment.en_US
dc.description.abstractResults: Our results showed that the breast tumor weight as well as lung and liver metastasis in mice could be reduced after herbal formula treatment for 4weeks. The breast tumor-induced osteolysis in mice was restored by herbal formula treatment, in which the bone volume in treated mice tibia was comparable to that in the non-tumor bearing normal mice. The IL-12 level was augmented and the survival of mice with metastatic breast tumors was prolonged after treatment. Furthermore, combination of herbal formula with chemotherapeutic agent doxorubicin resulted in better anti-tumor efficacy and increased life span in tumor-bearing mice, when compared with doxorubicin alone treatment.en_US
dc.description.abstractConclusions: In summary, our innovative Chinese herbal formula was demonstrated to possess anti-tumor, anti-metastatic and bone-protective activities in metastatic breast tumor-bearing mice. The preclinical data generated in this study would lead to the development of evidence-based supplement as adjuvant therapy for metastatic breast cancer.en_US
dc.description.sponsorshipDepartment of Health Technology and Informaticsen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofChinese medicineen_US
dc.rights© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise state.en_US
dc.rightsThe following publication Yue, G. G. L., Lee, J. K. M., Chan, B. L., Kwok, H. F., Hoi, S. W. H., Sze, D. M. Y., . . . Lau, C. B. S. (2018). An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model. Chinese Medicine, 13, 64, 1-12 is available at
dc.subjectMetastatic breast canceren_US
dc.subjectChinese herbal medicinesen_US
dc.subjectAndrographis paniculataen_US
dc.subjectAcanthopanax senticosusen_US
dc.subjectCamellia sinensisen_US
dc.subjectHedyotis diffusaen_US
dc.titleAn innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse modelen_US
dc.typeJournal/Magazine Articleen_US
dc.description.validate201903 bcrc-
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