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Title: EBNA1-targeted inhibitors : novel approaches for the treatment of Epstein-Barr virus-associated cancers
Authors: Jiang, LJ
Xie, C
Lung, HL
Lo, KW
Law, GL 
Mak, NK
Wong, KL
Keywords: EBNA1-targeted inhibitor
Fluorescent probe
EBV-associated cancers
Issue Date: 2018
Publisher: Ivyspring International Publisher
Source: Theranostics, 2018, v. 8, no. 19, p. 5307-5319 How to cite?
Journal: Theranostics 
Abstract: Epstein-Barr virus (EBV) infects more than 90% of humans worldwide and establishes lifelong latent infection in the hosts. It is closely associated with endemic forms of a wide range of human cancers and directly contributes to the formation of some. Despite its critical role in cancer development, no EBV-or EBV latent protein-targeted therapy is available. The EBV-encoded latent protein, Epstein-Barr nuclear antigen 1 (EBNA1), is expressed in all EBV-associated tumors and acts as the only latent protein in some of these tumors. This versatile protein functions in the maintenance, replication, and segregation of the EBV genome and can therefore serve as an attractive therapeutic target to treat EBV-associated cancers. In the last decades, efforts have been made for designing specific EBNA1 inhibitors to decrease EBNA1 expression or interfere with EBNA1-dependent functions. In this review, we will briefly introduce the salient features of EBNA1, summarize its functional domains, and focus on the recent developments in the identification and design of EBNA1 inhibitors related to various EBNA1 domains as well as discuss their comparative merits.
EISSN: 1838-7640
DOI: 10.7150/thno.26823
Rights: © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
The following publication Jiang, L.J., Xie, C., Lung, H.L., Lo, K.W., Law, G.L., Mak, N.K., & Wong, K.L. (2018). EBNA1-targeted inhibitors : novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics, 8 (19), 5307-5319 is available at
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