Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79839
Title: Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-kappa B and STAT3 signaling
Authors: Wong, WY 
Lee, MML 
Chan, BD 
Ma, VWS
Zhang, WC 
Yip, TTC
Wong, WT 
Tai, WCS 
Keywords: Gynostemma pentaphyllum saponins
Inflammatory bowel disease
Macrophages
Colitis
Anti-inflammation
Issue Date: 2017
Publisher: Impact Journals LLC
Source: Oncotarget, 20 Oct. 2017, v. 8, no. 50, p. 87401-87414 How to cite?
Journal: Oncotarget 
Abstract: Recent advances in the development of anti-inflammatory agents have improved their therapeutic outcome in inflammatory bowel disease (IBD), however, the presence of side effects and limited effectiveness hinder their widespread use. Therefore, novel compounds with strong anti-inflammatory efficacy are still required. In this study, we investigated the anti-inflammatory effect and potential mechanisms of Gynostemma pentaphyllum (Thunb.) Makino saponins (GpS), a major component of the herbal medicine widely used in Asian countries. In in vitro studies, we demonstrated that GpS dose dependently suppressed activation of macrophages, one of the main effectors in IBD. GpS also suppressed cytokine production and the activation of NF-kappa B and STAT3 signaling in lipopolysaccharide-induced macrophages, without affecting their viability. Further in vivo studies demonstrated that GpS could ameliorate the weight loss, increased disease activity index, colon shortening and histological damage associated with dextran sulfate sodium (DSS)-induced colitis in mice. In agreement with results from our in vitro experiments, GpS suppressed cytokine production and activation of NF-kappa B and STAT3 signaling in the colons of DSS-induced mice. In this study, we present for the first time, evidence of the therapeutic effect of GpS in IBD, highlighting its potential as an effective therapeutic against the disease.
URI: http://hdl.handle.net/10397/79839
ISSN: 1949-2553
DOI: 10.18632/oncotarget.20997
Rights: Copyright: Wong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication Wong, W. Y., Lee, M. M. L., Chan, B. D., Ma, V. W. S., Zhang, W. C., Yip, T. T. C., … & Tai, W. C. S. (2017). Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-kappa B and STAT3 signaling. Oncotarget, 8(50), 87401-87414 is available at https://dx.doi.org/10.18632/oncotarget.20997
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