Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79839
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.contributorChinese Mainland Affairs Office-
dc.creatorWong, WY-
dc.creatorLee, MML-
dc.creatorChan, BD-
dc.creatorMa, VWS-
dc.creatorZhang, WC-
dc.creatorYip, TTC-
dc.creatorWong, WT-
dc.creatorTai, WCS-
dc.date.accessioned2018-12-21T07:13:35Z-
dc.date.available2018-12-21T07:13:35Z-
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://hdl.handle.net/10397/79839-
dc.language.isoenen_US
dc.publisherImpact Journals LLCen_US
dc.rightsCopyright: Wong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rightsThe following publication Wong, W. Y., Lee, M. M. L., Chan, B. D., Ma, V. W. S., Zhang, W. C., Yip, T. T. C., … & Tai, W. C. S. (2017). Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-kappa B and STAT3 signaling. Oncotarget, 8(50), 87401-87414 is available at https://dx.doi.org/10.18632/oncotarget.20997en_US
dc.subjectGynostemma pentaphyllum saponinsen_US
dc.subjectInflammatory bowel diseaseen_US
dc.subjectMacrophagesen_US
dc.subjectColitisen_US
dc.subjectAnti-inflammationen_US
dc.titleGynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-kappa B and STAT3 signalingen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage87401en_US
dc.identifier.epage87414en_US
dc.identifier.volume8en_US
dc.identifier.issue50en_US
dc.identifier.doi10.18632/oncotarget.20997en_US
dcterms.abstractRecent advances in the development of anti-inflammatory agents have improved their therapeutic outcome in inflammatory bowel disease (IBD), however, the presence of side effects and limited effectiveness hinder their widespread use. Therefore, novel compounds with strong anti-inflammatory efficacy are still required. In this study, we investigated the anti-inflammatory effect and potential mechanisms of Gynostemma pentaphyllum (Thunb.) Makino saponins (GpS), a major component of the herbal medicine widely used in Asian countries. In in vitro studies, we demonstrated that GpS dose dependently suppressed activation of macrophages, one of the main effectors in IBD. GpS also suppressed cytokine production and the activation of NF-kappa B and STAT3 signaling in lipopolysaccharide-induced macrophages, without affecting their viability. Further in vivo studies demonstrated that GpS could ameliorate the weight loss, increased disease activity index, colon shortening and histological damage associated with dextran sulfate sodium (DSS)-induced colitis in mice. In agreement with results from our in vitro experiments, GpS suppressed cytokine production and activation of NF-kappa B and STAT3 signaling in the colons of DSS-induced mice. In this study, we present for the first time, evidence of the therapeutic effect of GpS in IBD, highlighting its potential as an effective therapeutic against the disease.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationOncotarget, 20 Oct. 2017, v. 8, no. 50, p. 87401-87414-
dcterms.isPartOfOncotarget-
dcterms.issued2017-
dc.identifier.isiWOS:000413341400034-
dc.identifier.pmid29152090-
dc.identifier.rosgroupid2017005255-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201812 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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