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Title: Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism
Authors: Cao, S 
Dong, XL 
Ho, MX 
Yu, WX 
Wong, KC 
Yao, XS
Wong, MS 
Issue Date: Feb-2018
Source: Nutrients, Feb. 2018, v. 10, no. 2, 247, p. 1-20
Abstract: Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)2D3 and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats. In addition, OA significantly increased renal CYP27B1 mRNA and promoter activity, and suppressed CYP24A1 mRNA and protein expressions in human proximal tubule HKC-8 cells. OA exerted bone protective effects in mature OVX mice and aged female rats. This action on bone might be, at least in part, associated with its effects on Ca and vitamin D metabolism. The present findings suggest that OA is a potential drug candidate for the management of postmenopausal osteoporosis.
Keywords: Aging
Calcium
Oleanolic acid
Osteoporosis
Ovariectomised
Vitamin D
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: Nutrients 
ISSN: 2072-6643
DOI: 10.3390/nu10020247
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The following publication Cao, S.; Dong, X.-L.; Ho, M.-X.; Yu, W.-X.; Wong, K.-C.; Yao, X.-S.; Wong, M.-S. Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. Nutrients 2018, 10, 247 is available at https://dx.doi.org/10.3390/nu10020247
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