Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/77855
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Cao, S | en_US |
dc.creator | Dong, XL | en_US |
dc.creator | Ho, MX | en_US |
dc.creator | Yu, WX | en_US |
dc.creator | Wong, KC | en_US |
dc.creator | Yao, XS | en_US |
dc.creator | Wong, MS | en_US |
dc.date.accessioned | 2018-08-28T01:35:14Z | - |
dc.date.available | 2018-08-28T01:35:14Z | - |
dc.identifier.issn | 2072-6643 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/77855 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Cao, S.; Dong, X.-L.; Ho, M.-X.; Yu, W.-X.; Wong, K.-C.; Yao, X.-S.; Wong, M.-S. Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. Nutrients 2018, 10, 247 is available at https://dx.doi.org/10.3390/nu10020247 | en_US |
dc.subject | Aging | en_US |
dc.subject | Calcium | en_US |
dc.subject | Oleanolic acid | en_US |
dc.subject | Osteoporosis | en_US |
dc.subject | Ovariectomised | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 20 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.3390/nu10020247 | en_US |
dcterms.abstract | Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)2D3 and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats. In addition, OA significantly increased renal CYP27B1 mRNA and promoter activity, and suppressed CYP24A1 mRNA and protein expressions in human proximal tubule HKC-8 cells. OA exerted bone protective effects in mature OVX mice and aged female rats. This action on bone might be, at least in part, associated with its effects on Ca and vitamin D metabolism. The present findings suggest that OA is a potential drug candidate for the management of postmenopausal osteoporosis. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Nutrients, Feb. 2018, v. 10, no. 2, 247, p. 1-20 | en_US |
dcterms.isPartOf | Nutrients | en_US |
dcterms.issued | 2018-02 | - |
dc.identifier.isi | WOS:000427540000137 | - |
dc.identifier.scopus | 2-s2.0-85042502592 | - |
dc.identifier.artn | 247 | en_US |
dc.identifier.rosgroupid | 2017004573 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in policy or professional journal | en_US |
dc.description.validate | 201808 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA, a1375 | - |
dc.identifier.SubFormID | 44728 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China (81528024);The Hong Kong Polytechnic University Central Allocation fund (15100015);Collaborative Research Fund PolyU support for shortlisted proposal (1BBAB);Shenzhen Basic Research Program (JCYJ20151030164008764);Research Studentship of the Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Cao_Oleanolic_Acid_Osteoprotective.pdf | 1.41 MB | Adobe PDF | View/Open |
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