Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/75880
Title: | The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice | Authors: | Tse, DY Kim, SJ Chung, I He, F Wensel, TG Wu, SM |
Issue Date: | 2017 | Source: | International journal of ophthalmology, 2017, v. 10, no. 9, p. 1361-1369 | Abstract: | AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle and was used as a control. Bilateral dark-adapted electroretinography (ERG) was performed 1 and 7d following injection. Histology was examined using a combination of light, fluorescence and electron microscopy. High-performance liquid chromatography (HPLC) was used to determine the decay in the retinal simvastatin concentration. RESULTS: ERG revealed no significant changes in the simvastatin-injected eyes compared to control. Histologic studies showed normal retinal morphology in eyes injected with simvastatin up to a final vitreal concentration of 200 μmol/L. No significant changes in the number of photoreceptors, bipolar cells or ganglion cells were found. The retinal simvastatin concentration decayed exponentially, with a half-life of 1.92-2.41h. CONCLUSION: Intravitreal injection of up to 200 μmol/L simvastatin produced no signs of adverse effects in the mouse retina. Simvastatin reaches the retina shortly after intravitreal injectionand has a short half-life. |
Keywords: | Simvastatin Retina Electroretinography High-performance liquid chromatography Electron microscopy Intravitreal injection |
Publisher: | International Council of Ophthalmology | Journal: | International journal of ophthalmology | ISSN: | 2222-3959 | EISSN: | 2227-4898 | DOI: | 10.18240/ijo.2017.09.05 | Rights: | All content of the IJO is published with open access under the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/). All articles published with open access will be immediately and permanently free for everyone to read, download, copy, and distribute as defined by the applied license. The following publication :Y D. Tse,Seong Jae Kim,Inyoung Chung,Feng He,Theodore G. Wensel,Samuel M. Wu.The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice.Int J Ophthalmol 2017;10(9):1361-1369 is available at 10.18240/ijo.2017.09.05. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
create_pdf.pdf | 3.42 MB | Adobe PDF | View/Open |
Page views
85
Last Week
0
0
Last month
Citations as of Apr 21, 2024
Downloads
28
Citations as of Apr 21, 2024
SCOPUSTM
Citations
5
Last Week
0
0
Last month
Citations as of Apr 19, 2024
WEB OF SCIENCETM
Citations
5
Last Week
0
0
Last month
Citations as of Apr 25, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.