Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/75880
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | en_US |
dc.creator | Tse, DY | en_US |
dc.creator | Kim, SJ | en_US |
dc.creator | Chung, I | en_US |
dc.creator | He, F | en_US |
dc.creator | Wensel, TG | en_US |
dc.creator | Wu, SM | en_US |
dc.date.accessioned | 2018-05-10T02:54:50Z | - |
dc.date.available | 2018-05-10T02:54:50Z | - |
dc.identifier.issn | 2222-3959 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/75880 | - |
dc.language.iso | en | en_US |
dc.publisher | International Council of Ophthalmology | en_US |
dc.rights | All content of the IJO is published with open access under the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/). All articles published with open access will be immediately and permanently free for everyone to read, download, copy, and distribute as defined by the applied license. | en_US |
dc.rights | The following publication :Y D. Tse,Seong Jae Kim,Inyoung Chung,Feng He,Theodore G. Wensel,Samuel M. Wu.The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice.Int J Ophthalmol 2017;10(9):1361-1369 is available at 10.18240/ijo.2017.09.05. | en_US |
dc.subject | Simvastatin | en_US |
dc.subject | Retina | en_US |
dc.subject | Electroretinography | en_US |
dc.subject | High-performance liquid chromatography | en_US |
dc.subject | Electron microscopy | en_US |
dc.subject | Intravitreal injection | en_US |
dc.title | The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1361 | en_US |
dc.identifier.epage | 1369 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.doi | 10.18240/ijo.2017.09.05 | en_US |
dcterms.abstract | AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. | en_US |
dcterms.abstract | METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle and was used as a control. Bilateral dark-adapted electroretinography (ERG) was performed 1 and 7d following injection. Histology was examined using a combination of light, fluorescence and electron microscopy. High-performance liquid chromatography (HPLC) was used to determine the decay in the retinal simvastatin concentration. | en_US |
dcterms.abstract | RESULTS: ERG revealed no significant changes in the simvastatin-injected eyes compared to control. Histologic studies showed normal retinal morphology in eyes injected with simvastatin up to a final vitreal concentration of 200 μmol/L. No significant changes in the number of photoreceptors, bipolar cells or ganglion cells were found. The retinal simvastatin concentration decayed exponentially, with a half-life of 1.92-2.41h. | en_US |
dcterms.abstract | CONCLUSION: Intravitreal injection of up to 200 μmol/L simvastatin produced no signs of adverse effects in the mouse retina. Simvastatin reaches the retina shortly after intravitreal injectionand has a short half-life. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of ophthalmology, 2017, v. 10, no. 9, p. 1361-1369 | en_US |
dcterms.isPartOf | International journal of ophthalmology | en_US |
dcterms.issued | 2017 | - |
dc.identifier.isi | WOS:000409558000005 | - |
dc.identifier.pmid | 28944193 | - |
dc.identifier.eissn | 2227-4898 | en_US |
dc.identifier.rosgroupid | 2017005530 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201805 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | SO-0075 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Institute of Health; Retina Research Foundation(Houston); Research to Prevent Blindness Inc. ; Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 6780528 | - |
Appears in Collections: | Journal/Magazine Article |
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create_pdf.pdf | 3.42 MB | Adobe PDF | View/Open |
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