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http://hdl.handle.net/10397/70645
Title: | Post-translational modifications and their applications in eye research | Authors: | Chen, BJ Lam, TC Liu, LQ To, CH |
Issue Date: | Jun-2017 | Source: | Molecular medicine reports, June 2017, v. 15, no. 6, p. 3923-3935 | Abstract: | Gene expression is the process by which genetic information is used for the synthesis of a functional gene product, and ultimately regulates cell function. The increase of biological complexity from genome to proteome is vast, and the post-translational modification (PTM) of proteins contribute to this complexity. The study of protein expression and PTMs has attracted attention in the post-genomic era. Due to the limited capability of conventional biochemical techniques in the past, large-scale PTM studies were technically challenging. The introduction of effective protein separation methods, specific PTM purification strategies and advanced mass spectrometers has enabled the global profiling of PTMs and the identification of a targeted PTM within the proteome. The present review provides an overview of current proteomic technologies being applied in eye research, with a particular focus on studies of PTMs in ocular tissues and ocular diseases. | Keywords: | Mass spectrometry Proteomics Post-translational modifications Ocular diseases |
Publisher: | Spandidos Publications | Journal: | Molecular medicine reports | ISSN: | 1791-2997 | EISSN: | 1791-3004 | DOI: | 10.3892/mmr.2017.6529 | Rights: | The following publication Chen, B., Lam, T.C., Liu, L., & To, C. (2017). Post-translational modifications and their applications in eye research (Review). Molecular Medicine Reports, 15, 3923-3935 is available at https://doi.org/10.3892/mmr.2017.6529. |
Appears in Collections: | Journal/Magazine Article |
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