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Title: Application of the transferrin receptor-mediated drug delivery systems in the treatment of acute cerebral infarction
Other Titles: 转铁蛋白受体介导的药物转运在急性脑梗死治疗中的应用
Authors: Wan, ZM
Bao, SY
Qian, ZM
Keywords: Transferrin
Cerebral infarction
Blood-brain barrier
Monoclonal antibodies
Issue Date: 2004
Publisher: 该杂志社
Source: 国外医学. 脑血管疾病分册 (Cerebrovascular diseases foreign medical sciences), 2004, v. 12, no. 4, p. 301-303 How to cite?
Journal: 国外医学. 脑血管疾病分册 (Cerebrovascular diseases foreign medical sciences) 
Abstract: 在急性脑缺血的超早期,完整的血脑屏障(BBB)使许多治疗药物无法在有效治疗时间窗内进入脑组织发挥作用。转铁蛋白受体(TfR)单克隆抗体能有效通过受体介导的细胞内吞作用使结合的药物通过BBB,从而大大增加了治疗药物的定向选择性,使之更好地发挥治疗作用。
In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brain barrier (BBB) and enter brain tissues within the effective time window. The transferrin receptor(TfR) monoclonal antibodies can effectively penetrate BBB via receptor-mediated endocytosis and make the combined drugs penetrate BBB, and thus increasing the orientation selectivity of the therapeutic drugs considerably, and developing their better therapeutic effect.
ISSN: 1673-4165
Rights: © 2004 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。
© 2004 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.
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