Stem cell transplantation therapies in Parkinson’s disease

Abstract

帕金森病 (Parkinson’sdisease,PD)是一种人类常见的中枢神经系统退行性疾病 ,主要病理变化是黑质多巴胺神经元损伤 ,是干细胞治疗的最佳适应证之一。动物模型的研究证实 ,干细胞移植可以替代丧失的神经元 ,恢复脑功能和促进脑的自我修复。临床试验显示干细胞移植在PD病人脑部也可达到类似的结果。这些研究展示了干细胞移植临床应用治疗PD的良好前景。然而 ,这样的治疗是否可以永久和完全恢复PD的脑功能仍是一个疑问。 After Alzheimer’s disease, Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by gradual loss of nigrostriatal dopamine neurons.This disorder is particularly suitable for testing stem cell transplantation approaches. In animal models,it was demonstrated that stem cell implanted could develop and replace lost neurons and restore brain function.Clinical trials in PD suggest that similar approaches might also work in the diseased human brain. However, at present, it is unknown whether this treatment leads to recovery completely and permanently in PD. Further study is needed.