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Title: Chemical and pharmacological evaluations on the extract of Scutellaria Baicalensis Georgi (Huang-Qin) prepared by various extraction methods
Authors: Zhou, X
Choi, PS
Yang, JM
Hoi, PM
Lee, SMY
Leung, GPH
Ngai, SM
Kong, SK
Ho, HP
Wong, MYM
Chan, SW
Yeung, JHK
Kwan, YW
Keywords: Antioxidant properties
Extraction efficiency
Herb–drug interaction
Scutellaria baicalensis Georgi
Issue Date: 2016
Publisher: SpringerOpen
Source: SpringerPlus, 2016, v. 5, no. 1, 1438 How to cite?
Journal: SpringerPlus 
Abstract: Background: This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi.
Results: The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb–drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs.
Conclusion: MAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety.
ISSN: 2193-1801
DOI: 10.1186/s40064-016-3115-3
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