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http://hdl.handle.net/10397/62148
Title: | Chemical and pharmacological evaluations on the extract of Scutellaria Baicalensis Georgi (Huang-Qin) prepared by various extraction methods | Authors: | Zhou, X Choi, PS Yang, JM Or, PMY Hoi, PM Lee, SMY Leung, GPH Ngai, SM Kong, SK Ho, HP Wong, MYM Chan, SW Yeung, JHK Kwan, YW |
Issue Date: | 2016 | Source: | SpringerPlus, 2016, v. 5, 1438, p. 1-10 | Abstract: | Background: This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi. Results: The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb–drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs. Conclusion: MAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety. |
Keywords: | Antioxidant properties Extraction efficiency Herb–drug interaction Scutellaria baicalensis Georgi |
Publisher: | SpringerOpen | Journal: | SpringerPlus | ISSN: | 2193-1801 | DOI: | 10.1186/s40064-016-3115-3 | Rights: | © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The following publication Zhou, X., Choi, P. S., Yang, J. M., Or, P. M. Y., Hoi, P. M., Lee, S. M. Y., … Kwan, Y. W. (2016). Chemical and pharmacological evaluations on the extract of Scutellaria Baicalensis Georgi (Huang-Qin) prepared by various extraction methods. Springerplus, 5, 1438, 1-10 is available at https://dx.doi.org/10.1186/s40064-016-3115-3 |
Appears in Collections: | Journal/Magazine Article |
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