Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61556
Title: Synthesis of lysine methyltransferase inhibitors
Authors: Hui, C
Ye, T 
Keywords: Epigenetics
Inhibitors
Lysine methyltransferase
S-adenosyl-l-methionine
Synthesis
Issue Date: 2015
Publisher: Frontiers Media SA
Source: Frontiers in chemistry, 2015, v. 3, no. Jul 2015, 44, p. 1-20 How to cite?
Journal: Frontiers in chemistry 
Abstract: Lysine methyltransferase which catalyze methylation of histone and non-histone proteins, play a crucial role in diverse biological processes and has emerged as a promising target for the development of various human diseases, including cancer, inflammation, and psychiatric disorders. However, inhibiting lysine methyltransferases selectively has presented many challenges to medicinal chemists. During the past decade, lysine methyltransferase inhibitors covering many different structural classes have been designed and developed. In this review, we describe the development of selective, small-molecule inhibitors of lysine methyltransferases with an emphasis on their discovery and chemical synthesis. We highlight the current state of lysine methyltransferase inhibitors and discuss future directions and opportunities for lysine methyltransferase inhibitor discovery.
URI: http://hdl.handle.net/10397/61556
ISSN: 2296-2646 (online)
DOI: 10.3389/fchem.2015.00044
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