Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/61556
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Hui, C | - |
dc.creator | Ye, T | - |
dc.date.accessioned | 2016-12-19T08:56:18Z | - |
dc.date.available | 2016-12-19T08:56:18Z | - |
dc.identifier.issn | 2296-2646 (online) | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/61556 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media SA | en_US |
dc.rights | Copyright © 2015 Hui and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights | The following publication Hui C and Ye T (2015) Synthesis of lysine methyltransferase inhibitors. Front. Chem. 3:44,1-20 is available at https://dx.doi.org/10.3389/fchem.2015.00044 | en_US |
dc.subject | Epigenetics | en_US |
dc.subject | Inhibitors | en_US |
dc.subject | Lysine methyltransferase | en_US |
dc.subject | S-adenosyl-l-methionine | en_US |
dc.subject | Synthesis | en_US |
dc.title | Synthesis of lysine methyltransferase inhibitors | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 20 | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.doi | 10.3389/fchem.2015.00044 | en_US |
dcterms.abstract | Lysine methyltransferase which catalyze methylation of histone and non-histone proteins, play a crucial role in diverse biological processes and has emerged as a promising target for the development of various human diseases, including cancer, inflammation, and psychiatric disorders. However, inhibiting lysine methyltransferases selectively has presented many challenges to medicinal chemists. During the past decade, lysine methyltransferase inhibitors covering many different structural classes have been designed and developed. In this review, we describe the development of selective, small-molecule inhibitors of lysine methyltransferases with an emphasis on their discovery and chemical synthesis. We highlight the current state of lysine methyltransferase inhibitors and discuss future directions and opportunities for lysine methyltransferase inhibitor discovery. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Frontiers in chemistry, 23 July 2015, v. 3, 44, p. 1-20 | - |
dcterms.isPartOf | Frontiers in chemistry | - |
dcterms.issued | 2015-07-23 | - |
dc.identifier.isi | WOS:000373363200001 | - |
dc.identifier.scopus | 2-s2.0-84969579998 | - |
dc.identifier.pmid | 26258118 | - |
dc.identifier.artn | 44 | en_US |
dc.identifier.rosgroupid | 2015003533 | - |
dc.description.ros | 2015-2016 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Hui_Lysine_Methyltransferase_Inhibitorse.pdf | 23.92 MB | Adobe PDF | View/Open |
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