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Title: Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity
Authors: Chung, PY
Tang, JCO 
Cheng, CH
Bian, ZX
Wong, WY
Lam, KH
Chui, CH
Issue Date: 2016
Source: SpringerPlus, 2016, v. 5, 271, p. 1-6
Abstract: Background: Candida susceptibility commonly occurs in breast cancer patients. Of which, Candida albicans is considered as a common pathogen causing candidiasis. Martinella iquitosensis (Bignoniaceae) is one of the species belonged to Martinella, distributed widely in Amazon basin. Its root extract yielded two complex substituted tetrahydroquinolines, Martinelline and Martinellic acid which were the first natural non-peptide bradykinin receptor antagonists identified.
Findings: In this study, a novel martinelline type analogue, named 2,3,3a,4,5,9b-hexahydro-8-phenoxy-4-(pyridin-2-yl)furo[3,2-c]quinoline, was synthesized and its preliminary anticancer activity and antifungal potential were investigated. This compound showed potential anticancer activity against MDAMB-231 breast cancer cells. Meanwhile it could enhance the fungistatic activity of miconazole against Candida albicans.
Conclusions: These findings provide an implication for the continue investigation and development of martinelline type analogues as therapeutic agents in the future.
Keywords: Biological activity
Candida albicans
Martinelline type analogue
Publisher: SpringerOpen
Journal: SpringerPlus 
ISSN: 2193-1801
DOI: 10.1186/s40064-016-1890-5
Rights: © 2016 Chung etal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
The following publication Chung, P. Y., Tang, J. C. O., Cheng, C. H., Bian, Z. X., Wong, W. Y., Lam, K. H., & Chui, C. H. (2016). Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity. Springerplus, 5, 271, 1-6 is available at
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