Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61251
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorChung, PY-
dc.creatorTang, JCO-
dc.creatorCheng, CH-
dc.creatorBian, ZX-
dc.creatorWong, WY-
dc.creatorLam, KH-
dc.creatorChui, CH-
dc.date.accessioned2016-12-19T08:55:19Z-
dc.date.available2016-12-19T08:55:19Z-
dc.identifier.issn2193-1801-
dc.identifier.urihttp://hdl.handle.net/10397/61251-
dc.language.isoenen_US
dc.publisherSpringerOpenen_US
dc.rights© 2016 Chung etal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.rightsThe following publication Chung, P. Y., Tang, J. C. O., Cheng, C. H., Bian, Z. X., Wong, W. Y., Lam, K. H., & Chui, C. H. (2016). Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity. Springerplus, 5, 271, 1-6 is available at https://dx.doi.org/10.1186/s40064-016-1890-5en_US
dc.subjectBiological activityen_US
dc.subjectCandida albicansen_US
dc.subjectHexahydrofuro[3,2-c]quinolineen_US
dc.subjectMartinelline type analogueen_US
dc.titleSynthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activityen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.epage6-
dc.identifier.volume5-
dc.identifier.doi10.1186/s40064-016-1890-5-
dcterms.abstractBackground: Candida susceptibility commonly occurs in breast cancer patients. Of which, Candida albicans is considered as a common pathogen causing candidiasis. Martinella iquitosensis (Bignoniaceae) is one of the species belonged to Martinella, distributed widely in Amazon basin. Its root extract yielded two complex substituted tetrahydroquinolines, Martinelline and Martinellic acid which were the first natural non-peptide bradykinin receptor antagonists identified.-
dcterms.abstractFindings: In this study, a novel martinelline type analogue, named 2,3,3a,4,5,9b-hexahydro-8-phenoxy-4-(pyridin-2-yl)furo[3,2-c]quinoline, was synthesized and its preliminary anticancer activity and antifungal potential were investigated. This compound showed potential anticancer activity against MDAMB-231 breast cancer cells. Meanwhile it could enhance the fungistatic activity of miconazole against Candida albicans.-
dcterms.abstractConclusions: These findings provide an implication for the continue investigation and development of martinelline type analogues as therapeutic agents in the future.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationSpringerPlus, 2016, v. 5, 271, p. 1-6-
dcterms.isPartOfSpringerPlus-
dcterms.issued2016-
dc.identifier.isiWOS:000373219600007-
dc.identifier.scopus2-s2.0-84963520625-
dc.identifier.pmid27006880-
dc.identifier.artn271-
dc.identifier.rosgroupid2015002186-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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