Ceruloplasmin and brain iron metabolism

Abstract

铜蓝蛋白 (Ceruloplasmin ,CP)是人体重要的亚铁氧化酶。它的主要作用是催化二价铁成为三价铁 ,从而促进铁与转铁蛋白结合。由于它的这一功能 ,过去三十年来 ,CP一直被认为参与细胞 (包括脑细胞 )铁释放。然而 ,最近的研究显示 ,这个传统的看法可能是错误的或者至少是不完全的。新的发现显示 ,脑内CP既有促进脑细胞铁释放也有铁摄取的作用。而且它对铁摄取作用可能比对铁释放的作用更为重要。本文讨论了这方面研究的最新进展 ,以及脑内CP表达异常在某些神经退行性疾病发生发展过程中的作用机制的新认识 Ceruloplasmin (CP) is a critical ferroxidase in humans. During the past three decades, it was widely believed that this protein has a role in iron release from cells, including brain cells. However, recent studies show that this view might not be completely right or accurate. New findings imply that CP might play a role both in iron release and iron uptake in brain cells. The involvement of CP in iron uptake might be a more important physiological role of CP than its role in iron release. In this short article we discussed recent advances in this aspect as well as the relationship between disregulation of CP and neurodegeneration. 还原