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Title: Reliability and validity study of clinical ultrasound imaging on lateral curvature of adolescent idiopathic scoliosis
Authors: Wang, Q 
Li, M 
Lou, EHM
Wong, MS 
Issue Date: 2015
Publisher: Public Library of Science
Source: PLoS one, 2015, v. 10, no. 8, e0135264 How to cite?
Journal: PLoS one 
Abstract: Background: Non-ionizing radiation imaging assessment has been advocated for the patients with adolescent idiopathic scoliosis (AIS). As one of the radiation-free methods, ultrasound imaging has gained growing attention in scoliosis assessment over the past decade. The center of laminae (COL) method has been proposed to measure the spinal curvature in the coronal plane of ultrasound image. However, the reliability and validity of this ultrasound method have not been validated in the clinical setting.
Objectives: To evaluate the reliability and validity of clinical ultrasound imaging on lateral curvature measurements of AIS with their corresponding magnetic resonance imaging (MRI) measurements.
Methods: Thirty curves (ranged 10.2°-68.2°) from sixteen patients with AIS were eligible for this study. The ultrasound scan was performed using a 3-D ultrasound unit within the same morning of MRI examination. Two researchers were involved in data collection of these two examinations. The COL method was used to measure the coronal curvature in ultrasound image, compared with the Cobb method in MRI. The intra-and inter-rater reliability of the COL method was evaluated by intra-class correlation coefficient (ICC). The validity of this method was analyzed by paired Student's t-test, Bland-Altman statistics and Pearson correlation coefficient. The level of significance was set as 0.05.
Results: The COL method showed high intra-and inter-rater reliabilities (both with ICC (2, K) >0.9, p<0.05) to measure the coronal curvature.compared with Cobb method, COL method showed no significant difference (p<0.05) when measuring coronal curvature. Furthermore, Bland-Altman method demonstrated an agreement between these two methods, and Pearson's correlation coefficient (r) was high (r>0.9, p<0.05).
Conclusion: The ultrasound imaging could provide a reliable and valid measurement of spinal curvature in the coronal plane using the COL method. Further research is needed to validate the proposed ultrasound measurement in larger clinical trial and to optimize the ultrasound scanning and measuring procedure.
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0135264
Rights: © 2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication: Wang Q, Li M, Lou EHM, Wong MS (2015) Reliability and Validity Study of Clinical Ultrasound Imaging on Lateral Curvature of Adolescent Idiopathic Scoliosis. PLoS ONE 10(8): e0135264 is available at
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