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Title: Method based on the β -lactamase PenPC fluorescent labeled for β -lactam antibiotic quantification in human plasma
Authors: Andresen, M
Wong, KY 
Leung, YC 
Wong, WT 
Chan, PH 
Andresen-Vasquez, M
Alegria, L
Silva, C
Tapia, P
Downey, P
Soto, D
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Source: BioMed research international, 2016, v. 2016, 4307987 How to cite?
Journal: BioMed research international 
Abstract: Recently, Wong et al. have successfully developed a fluorescent biosensor based on the PenPC β-lactamase which changes its intrinsic fluorescence in presence of β-lactam antibiotics (BLAs). Here, we studied systematically this correlation among the fluorescence change of the biosensor and the concentration of different BLAs aimed at developing a novel method for estimating the concentration of a wide range of BLAs. This method showed high precision and specificity and very low interference from clinically relevant samples. We were able to monitor the pharmacokinetics of meropenem in healthy volunteers as well as in an ill animal model too, indicating that the implemented method could be suitable for clinical practice.
ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2016/4307987
Rights: Copyright © 2016 Max Andresen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Andresen, M., Wong, K. Y., Leung, Y. C., Wong, W. T., Chan, P. H., Andresen-Vasquez, M., ... & Soto, D. (2016). Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma. BioMed research international, 2016, is available at https//
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