Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43398
Title: Method based on the β -lactamase PenPC fluorescent labeled for β -lactam antibiotic quantification in human plasma
Authors: Andresen, M
Wong, KY 
Leung, YC 
Wong, WT 
Chan, PH 
Andresen-Vasquez, M
Alegria, L
Silva, C
Tapia, P
Downey, P
Soto, D
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Source: BioMed research international, 2016, v. 2016, 4307987 How to cite?
Journal: BioMed research international 
Abstract: Recently, Wong et al. have successfully developed a fluorescent biosensor based on the PenPC β-lactamase which changes its intrinsic fluorescence in presence of β-lactam antibiotics (BLAs). Here, we studied systematically this correlation among the fluorescence change of the biosensor and the concentration of different BLAs aimed at developing a novel method for estimating the concentration of a wide range of BLAs. This method showed high precision and specificity and very low interference from clinically relevant samples. We were able to monitor the pharmacokinetics of meropenem in healthy volunteers as well as in an ill animal model too, indicating that the implemented method could be suitable for clinical practice.
URI: http://hdl.handle.net/10397/43398
ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2016/4307987
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

1
Last Week
0
Last month
Citations as of Sep 11, 2017

Page view(s)

41
Last Week
5
Last month
Checked on Sep 17, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.