Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/43398
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Andresen, M | - |
dc.creator | Wong, KY | - |
dc.creator | Leung, YC | - |
dc.creator | Wong, WT | - |
dc.creator | Chan, PH | - |
dc.creator | Andresen-Vasquez, M | - |
dc.creator | Alegria, L | - |
dc.creator | Silva, C | - |
dc.creator | Tapia, P | - |
dc.creator | Downey, P | - |
dc.creator | Soto, D | - |
dc.date.accessioned | 2016-06-07T06:16:10Z | - |
dc.date.available | 2016-06-07T06:16:10Z | - |
dc.identifier.issn | 2314-6133 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/43398 | - |
dc.language.iso | en | en_US |
dc.publisher | Hindawi Publishing Corporation | en_US |
dc.rights | Copyright © 2016 Max Andresen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following article: Andresen, M., Wong, K. Y., Leung, Y. C., Wong, W. T., Chan, P. H., Andresen-Vasquez, M., ... & Soto, D. (2016). Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma. BioMed research international, 2016, is available at https//doi.org/10.1155/2016/4307987 | en_US |
dc.title | Method based on the β -lactamase PenPC fluorescent labeled for β -lactam antibiotic quantification in human plasma | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 2016 | en_US |
dc.identifier.doi | 10.1155/2016/4307987 | en_US |
dcterms.abstract | Recently, Wong et al. have successfully developed a fluorescent biosensor based on the PenPC β-lactamase which changes its intrinsic fluorescence in presence of β-lactam antibiotics (BLAs). Here, we studied systematically this correlation among the fluorescence change of the biosensor and the concentration of different BLAs aimed at developing a novel method for estimating the concentration of a wide range of BLAs. This method showed high precision and specificity and very low interference from clinically relevant samples. We were able to monitor the pharmacokinetics of meropenem in healthy volunteers as well as in an ill animal model too, indicating that the implemented method could be suitable for clinical practice. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | BioMed research international, 2016, v. 2016, 4307987 | - |
dcterms.isPartOf | BioMed research international | - |
dcterms.issued | 2016 | - |
dc.identifier.isi | WOS:000369688900001 | - |
dc.identifier.scopus | 2-s2.0-84958078399 | - |
dc.identifier.eissn | 2314-6141 | en_US |
dc.identifier.rosgroupid | 2015000734 | - |
dc.description.ros | 2015-2016 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Andresen_Method_Based_Lactamase.pdf | 1.67 MB | Adobe PDF | View/Open |
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