Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43398
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorAndresen, M-
dc.creatorWong, KY-
dc.creatorLeung, YC-
dc.creatorWong, WT-
dc.creatorChan, PH-
dc.creatorAndresen-Vasquez, M-
dc.creatorAlegria, L-
dc.creatorSilva, C-
dc.creatorTapia, P-
dc.creatorDowney, P-
dc.creatorSoto, D-
dc.date.accessioned2016-06-07T06:16:10Z-
dc.date.available2016-06-07T06:16:10Z-
dc.identifier.issn2314-6133en_US
dc.identifier.urihttp://hdl.handle.net/10397/43398-
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright © 2016 Max Andresen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsThe following article: Andresen, M., Wong, K. Y., Leung, Y. C., Wong, W. T., Chan, P. H., Andresen-Vasquez, M., ... & Soto, D. (2016). Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma. BioMed research international, 2016, is available at https//doi.org/10.1155/2016/4307987en_US
dc.titleMethod based on the β -lactamase PenPC fluorescent labeled for β -lactam antibiotic quantification in human plasmaen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume2016en_US
dc.identifier.doi10.1155/2016/4307987en_US
dcterms.abstractRecently, Wong et al. have successfully developed a fluorescent biosensor based on the PenPC β-lactamase which changes its intrinsic fluorescence in presence of β-lactam antibiotics (BLAs). Here, we studied systematically this correlation among the fluorescence change of the biosensor and the concentration of different BLAs aimed at developing a novel method for estimating the concentration of a wide range of BLAs. This method showed high precision and specificity and very low interference from clinically relevant samples. We were able to monitor the pharmacokinetics of meropenem in healthy volunteers as well as in an ill animal model too, indicating that the implemented method could be suitable for clinical practice.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBioMed research international, 2016, v. 2016, 4307987-
dcterms.isPartOfBioMed research international-
dcterms.issued2016-
dc.identifier.isiWOS:000369688900001-
dc.identifier.scopus2-s2.0-84958078399-
dc.identifier.eissn2314-6141en_US
dc.identifier.rosgroupid2015000734-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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