Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/36131
Title: | Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors | Authors: | Yang, C Wong, ILK Jin, WB Jiang, T Chow, LMC Wan, SB |
Issue Date: | 2014 | Source: | Marine drugs, Oct. 2014, v. 12, no. 10, p. 5209-5221 | Abstract: | In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells. | Keywords: | Ningalin B analogues Multidrug resistance (MDR) Pyrrole P-glycoprotein P-gp modulators |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | Marine drugs | ISSN: | 1660-3397 | DOI: | 10.3390/md12105209 | Rights: | © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). The following publication Yang, C., Wong, I. L. K., Jin, W. B., Jiang, T., Chow, L. M. C., & Wan, S. B. (2014). Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors. Marine Drugs, 12(10), (Suppl. ), 5209-5221 is available athttps://dx.doi.org/10.3390/md12105209 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Yang_Marine_Natural_Product.pdf | 637.4 kB | Adobe PDF | View/Open |
Page views
128
Last Week
1
1
Last month
Citations as of Apr 14, 2024
Downloads
52
Citations as of Apr 14, 2024
SCOPUSTM
Citations
12
Last Week
0
0
Last month
Citations as of Apr 5, 2024
WEB OF SCIENCETM
Citations
10
Last Week
0
0
Last month
Citations as of Apr 18, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.