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Title: Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors
Authors: Yang, C
Wong, ILK
Jin, WB
Jiang, T
Chow, LMC 
Wan, SB
Keywords: Ningalin B analogues
Multidrug resistance (MDR)
P-gp modulators
Issue Date: 2014
Publisher: Molecular Diversity Preservation International (MDPI)
Source: Marine drugs, 2014, v. 12, no. 10, p. 5209-5221 How to cite?
Journal: Marine drugs 
Abstract: In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.
ISSN: 1660-3397
DOI: 10.3390/md12105209
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