Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36131
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorYang, C-
dc.creatorWong, ILK-
dc.creatorJin, WB-
dc.creatorJiang, T-
dc.creatorChow, LMC-
dc.creatorWan, SB-
dc.date.accessioned2016-04-15T08:36:32Z-
dc.date.available2016-04-15T08:36:32Z-
dc.identifier.issn1660-3397-
dc.identifier.urihttp://hdl.handle.net/10397/36131-
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rights© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rightsThe following publication Yang, C., Wong, I. L. K., Jin, W. B., Jiang, T., Chow, L. M. C., & Wan, S. B. (2014). Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors. Marine Drugs, 12(10), (Suppl. ), 5209-5221 is available athttps://dx.doi.org/10.3390/md12105209en_US
dc.subjectNingalin B analoguesen_US
dc.subjectMultidrug resistance (MDR)en_US
dc.subjectPyrroleen_US
dc.subjectP-glycoproteinen_US
dc.subjectP-gp modulatorsen_US
dc.titleModification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitorsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage5209-
dc.identifier.epage5221-
dc.identifier.volume12-
dc.identifier.issue10-
dc.identifier.doi10.3390/md12105209-
dcterms.abstractIn this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationMarine drugs, Oct. 2014, v. 12, no. 10, p. 5209-5221-
dcterms.isPartOfMarine drugs-
dcterms.issued2014-
dc.identifier.isiWOS:000344359200010-
dc.identifier.scopus2-s2.0-84908199216-
dc.identifier.pmid25329704-
dc.identifier.rosgroupid2014004255-
dc.description.ros2014-2015 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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