Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/36131
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Yang, C | - |
dc.creator | Wong, ILK | - |
dc.creator | Jin, WB | - |
dc.creator | Jiang, T | - |
dc.creator | Chow, LMC | - |
dc.creator | Wan, SB | - |
dc.date.accessioned | 2016-04-15T08:36:32Z | - |
dc.date.available | 2016-04-15T08:36:32Z | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | http://hdl.handle.net/10397/36131 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Yang, C., Wong, I. L. K., Jin, W. B., Jiang, T., Chow, L. M. C., & Wan, S. B. (2014). Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors. Marine Drugs, 12(10), (Suppl. ), 5209-5221 is available athttps://dx.doi.org/10.3390/md12105209 | en_US |
dc.subject | Ningalin B analogues | en_US |
dc.subject | Multidrug resistance (MDR) | en_US |
dc.subject | Pyrrole | en_US |
dc.subject | P-glycoprotein | en_US |
dc.subject | P-gp modulators | en_US |
dc.title | Modification of marine natural product Ningalin B and SAR study lead to potent P-Glycoprotein inhibitors | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 5209 | - |
dc.identifier.epage | 5221 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 10 | - |
dc.identifier.doi | 10.3390/md12105209 | - |
dcterms.abstract | In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Marine drugs, Oct. 2014, v. 12, no. 10, p. 5209-5221 | - |
dcterms.isPartOf | Marine drugs | - |
dcterms.issued | 2014 | - |
dc.identifier.isi | WOS:000344359200010 | - |
dc.identifier.scopus | 2-s2.0-84908199216 | - |
dc.identifier.pmid | 25329704 | - |
dc.identifier.rosgroupid | 2014004255 | - |
dc.description.ros | 2014-2015 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Yang_Marine_Natural_Product.pdf | 637.4 kB | Adobe PDF | View/Open |
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