Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28224
Title: Impaired executive function can predict recurrent falls in Parkinson's disease
Authors: Mak, MK 
Keywords: Accidental falls
Executive function
Parkinson disease
Prospective study
Rehabilitation
Issue Date: 2014
Publisher: W.B. Saunders
Source: Archives of physical medicine and rehabilitation, 2014, v. 95, no. 12, p. 2390-2395 How to cite?
Journal: Archives of physical medicine and rehabilitation 
Abstract: OBJECTIVE: To examine whether impairment in executive function independently predicts recurrent falls in people with Parkinson's disease (PD).DESIGN: Prospective cohort study.SETTING: University motor control research laboratory.PARTICIPANTS: A convenience sample of community-dwelling people with PD (N=144) was recruited from a patient self-help group and movement disorders clinics.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Executive function was assessed with the Mattis Dementia Rating Scale Initiation/Perseveration (MDRS-IP) subtest, and fear of falling (FoF) with the Activities-specific Balance Confidence (ABC) Scale. All participants were followed up for 12 months to record the number of monthly fall events.RESULTS: Forty-two people with PD had at least 2 falls during the follow-up period and were classified as recurrent fallers. After accounting for demographic variables and fall history (P=.001), multiple logistic regression analysis showed that the ABC scores (P=.014) and MDRS-IP scores (P=.006) were significantly associated with future recurrent falls among people with PD. The overall accuracy of the prediction was 85.9%. With the use of the significant predictors identified in multiple logistic regression analysis, a prediction model determined by the logistic function was generated: Z = 1.544 + .378 (fall history) - .045 (ABC) - .145 (MDRS-IP).CONCLUSIONS: Impaired executive function is a significant predictor of future recurrent falls in people with PD. Participants with executive dysfunction and greater FoF at baseline had a significantly greater risk of sustaining a recurrent fall within the subsequent 12 months.
URI: http://hdl.handle.net/10397/28224
ISSN: 0003-9993
EISSN: 1532-821X
DOI: 10.1016/j.apmr.2014.08.006
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