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http://hdl.handle.net/10397/2535
Title: | Telomerase-associated apoptotic events by mushroom Ganoderma lucidum on premalignant human urothelial cells | Authors: | Yuen, JWM Gohel, MDI Au, DWT |
Issue Date: | Jan-2008 | Source: | Nutrition and cancer, Jan. 2008, v. 60, no. 1, p. 109-119 | Abstract: | The chemopreventive effects of Ganoderma lucidum was tested, using a tumorigenic transformable human urothelial cell (HUCPC) model. These in vitro data show that G. lucidum can inhibit the viability and growth of HUC-PC. This could be explained by a concomitant induction of apoptosis and inhibition of telomerase activity. Significant exteriorization of phosphatidylserine was detected by Annexin-V on cell surface, and the cells subsequently lost membrane integrity for uptake of 7-amino-actinomycin D dye. Additionally, the levels of hydrogen peroxide and 8-hydroxy-2'- deoxyguanosine (8-OHdG) production of the apoptotic cells were significantly increased. The induction of apoptosis and suppression of telomerase activity help to explain the anti-HUC-PC growth properties; however, the induction of oxidative stress requires further study. This study strongly suggests that G. lucidum is a potential source of chemopreventive agents for bladder cancer based on its effectiveness in controlling the premalignant urothelial cell growth and carcinogen-induced transformation. | Keywords: | Ganoderma lucidum Triterpenes Bladder cancer Apoptosis Telomerase Prevention |
Publisher: | Routledge, Taylor & Francis Group | Journal: | Nutrition and cancer | ISSN: | 0163-5581 | EISSN: | 1532-7914 | DOI: | 10.1080/01635580701525869 | Rights: | © 2008 Taylor & Francis Group, LLC. This is an electronic version of an article published in J.W.M. Yuen, M.D.I. Gohel and D.W.T. Au (2008), Nutrition and Cancer, 60(1), 109-119. Nutrition and Cancer is available online at: http://www.informaworld.com, and the article at: http://www.informaworld.com/smpp/content~db=all~content=a789135069~frm=titlelink |
Appears in Collections: | Journal/Magazine Article |
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Ganoderma lucidum.pdf | Pre-published version | 1.5 MB | Adobe PDF | View/Open |
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