Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/2535
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Yuen, JWM | - |
dc.creator | Gohel, MDI | - |
dc.creator | Au, DWT | - |
dc.date.accessioned | 2014-12-11T08:23:15Z | - |
dc.date.available | 2014-12-11T08:23:15Z | - |
dc.identifier.issn | 0163-5581 | - |
dc.identifier.uri | http://hdl.handle.net/10397/2535 | - |
dc.language.iso | en | en_US |
dc.publisher | Routledge, Taylor & Francis Group | en_US |
dc.rights | © 2008 Taylor & Francis Group, LLC. This is an electronic version of an article published in J.W.M. Yuen, M.D.I. Gohel and D.W.T. Au (2008), Nutrition and Cancer, 60(1), 109-119. Nutrition and Cancer is available online at: http://www.informaworld.com, and the article at: http://www.informaworld.com/smpp/content~db=all~content=a789135069~frm=titlelink | en_US |
dc.subject | Ganoderma lucidum | en_US |
dc.subject | Triterpenes | en_US |
dc.subject | Bladder cancer | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Telomerase | en_US |
dc.subject | Prevention | en_US |
dc.title | Telomerase-associated apoptotic events by mushroom Ganoderma lucidum on premalignant human urothelial cells | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.description.otherinformation | Author name used in this publication: Mayur Danny I. Gohel | en_US |
dc.identifier.spage | 109 | - |
dc.identifier.epage | 119 | - |
dc.identifier.volume | 60 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1080/01635580701525869 | - |
dcterms.abstract | The chemopreventive effects of Ganoderma lucidum was tested, using a tumorigenic transformable human urothelial cell (HUCPC) model. These in vitro data show that G. lucidum can inhibit the viability and growth of HUC-PC. This could be explained by a concomitant induction of apoptosis and inhibition of telomerase activity. Significant exteriorization of phosphatidylserine was detected by Annexin-V on cell surface, and the cells subsequently lost membrane integrity for uptake of 7-amino-actinomycin D dye. Additionally, the levels of hydrogen peroxide and 8-hydroxy-2'- deoxyguanosine (8-OHdG) production of the apoptotic cells were significantly increased. The induction of apoptosis and suppression of telomerase activity help to explain the anti-HUC-PC growth properties; however, the induction of oxidative stress requires further study. This study strongly suggests that G. lucidum is a potential source of chemopreventive agents for bladder cancer based on its effectiveness in controlling the premalignant urothelial cell growth and carcinogen-induced transformation. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Nutrition and cancer, Jan. 2008, v. 60, no. 1, p. 109-119 | - |
dcterms.isPartOf | Nutrition and cancer | - |
dcterms.issued | 2008-01 | - |
dc.identifier.isi | WOS:000252647500014 | - |
dc.identifier.scopus | 2-s2.0-38749140639 | - |
dc.identifier.pmid | 18444142 | - |
dc.identifier.eissn | 1532-7914 | - |
dc.identifier.rosgroupid | r37573 | - |
dc.description.ros | 2007-2008 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ganoderma lucidum.pdf | Pre-published version | 1.5 MB | Adobe PDF | View/Open |
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