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Title: Studies toward the total synthesis of itralamide B and biological evaluation of its structural analogs
Authors: Wang, X
Lv, C
Feng, J
Tang, L
Wang, Z
Liu, Y
Meng, Y
Ye, T 
Xu, Z
Keywords: Biological study
Itralamide B
Structural analogs
Total synthesis
Issue Date: 2015
Publisher: MDPI AG
Source: Marine drugs, 2015, v. 13, no. 4, p. 2085-2104 How to cite?
Journal: Marine Drugs 
Abstract: Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 £gM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners.
ISSN: 1660-3397
DOI: 10.3390/md13042085
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