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|Title:||Studies toward the total synthesis of itralamide B and biological evaluation of its structural analogs|
|Source:||Marine drugs, 2015, v. 13, no. 4, p. 2085-2104 How to cite?|
|Abstract:||Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 £gM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners.|
|Appears in Collections:||Journal/Magazine Article|
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Checked on Feb 26, 2017
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