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http://hdl.handle.net/10397/25071
| Title: | Studies toward the total synthesis of itralamide B and biological evaluation of its structural analogs | Authors: | Wang, X Lv, C Feng, J Tang, L Wang, Z Liu, Y Meng, Y Ye, T Xu, Z |
Issue Date: | 2015 | Source: | Marine drugs, Apr. 2015, v. 13, no. 4, p. 2085-2104 | Abstract: | Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 £gM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners. | Keywords: | Biological study Cyclodepsipeptide Itralamide B Structural analogs Total synthesis |
Publisher: | MDPI AG | Journal: | Marine Drugs | ISSN: | 1660-3397 | DOI: | 10.3390/md13042085 | Rights: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). The following publication is available at Wang, X.; Lv, C.; Feng, J.; Tang, L.; Wang, Z.; Liu, Y.; Meng, Y.; Ye, T.; Xu, Z. Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs. Mar. Drugs 2015, 13, 2085-2104://dx.doi.org/10.3390/md13042085 |
| Appears in Collections: | Journal/Magazine Article |
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| Wang_Synthesis_Itralamide_B.pdf | 961.37 kB | Adobe PDF | View/Open |
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