Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10573
Title: Sulfation and enhanced antioxidant capacity of an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis
Authors: Yan, JK
Wang, WQ
Ma, HL
Wu, JY 
Keywords: Antioxidant activity
Cordyceps sinensis
Exopolysaccharide
Molecular weight
Sulfation
Issue Date: 2013
Publisher: Mdpi Ag
Source: Molecules, 2013, v. 18, no. 1, p. 167-177 How to cite?
Journal: Molecules 
Abstract: EPS-1 was an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis (Cs-HK1). In the present study, EPS-1 was sulfated with chlorosulfonic acid (CSA)-pyridine (Pyr) at different volume ratios, yielding four sulfated derivatives, SEPS-1A, B, C and D, with different degrees of substitution (DS: 0.25-1.38) and molecular weights (17.1-4.1 kDa). The sulfation of EPS-1 occurred most frequently at the C-6 hydroxyl groups due to their higher reactivity. In aqueous solution, the native EPS-1 formed random coils or aggregated networks, but the sulfated derivatives formed single helices. The antioxidant activities of the sulfated EPS-1 derivatives for scavenging hydroxyl radicals (·OH) and 2,2-Azinobis-3-ehtylbenzothiazolin-6-sulfonic acid radicals (ABTS·+) were significantly increased with increasing DS and decreasing molecular weight (MW). Sulfation has thus been shown to be an effective and favorable strategy for improving the physico-chemical properties and bioactivities of fungal polysaccharides.
URI: http://hdl.handle.net/10397/10573
ISSN: 1420-3049
DOI: 10.3390/molecules18010167
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