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http://hdl.handle.net/10397/10573
Title: | Sulfation and enhanced antioxidant capacity of an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis | Authors: | Yan, JK Wang, WQ Ma, HL Wu, JY |
Issue Date: | 2013 | Source: | Molecules, Jan. 2013, v. 18, no. 1, p. 167-177 | Abstract: | EPS-1 was an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis (Cs-HK1). In the present study, EPS-1 was sulfated with chlorosulfonic acid (CSA)-pyridine (Pyr) at different volume ratios, yielding four sulfated derivatives, SEPS-1A, B, C and D, with different degrees of substitution (DS: 0.25-1.38) and molecular weights (17.1-4.1 kDa). The sulfation of EPS-1 occurred most frequently at the C-6 hydroxyl groups due to their higher reactivity. In aqueous solution, the native EPS-1 formed random coils or aggregated networks, but the sulfated derivatives formed single helices. The antioxidant activities of the sulfated EPS-1 derivatives for scavenging hydroxyl radicals (·OH) and 2,2-Azinobis-3-ehtylbenzothiazolin-6-sulfonic acid radicals (ABTS·+) were significantly increased with increasing DS and decreasing molecular weight (MW). Sulfation has thus been shown to be an effective and favorable strategy for improving the physico-chemical properties and bioactivities of fungal polysaccharides. | Keywords: | Antioxidant activity Cordyceps sinensis Exopolysaccharide Molecular weight Sulfation |
Publisher: | Mdpi Ag | Journal: | Molecules | ISSN: | 1420-3049 | DOI: | 10.3390/molecules18010167 | Rights: | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). The following publication Yan, J. K., Wang, W. Q., Ma, H. L., & Wu, J. Y. (2013). Sulfation and enhanced antioxidant capacity of an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis. Molecules, 18(1), (Suppl. ), 167-177 is available athttps://dx.doi.org/10.3390/molecules18010167 |
Appears in Collections: | Journal/Magazine Article |
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