Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/99976
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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorHe, Xen_US
dc.creatorLi, Yen_US
dc.creatorMiao, Hen_US
dc.creatorXu, Jen_US
dc.creatorOng, MTYen_US
dc.creatorWang, Cen_US
dc.creatorZheng, Len_US
dc.creatorWang, Jen_US
dc.creatorHuang, Len_US
dc.creatorZu, Hen_US
dc.creatorYao, Zen_US
dc.creatorMi, Jen_US
dc.creatorDai, Ben_US
dc.creatorLi, Xen_US
dc.creatorYung, PSHen_US
dc.creatorYuan, Gen_US
dc.creatorQin, Len_US
dc.date.accessioned2023-07-26T05:49:35Z-
dc.date.available2023-07-26T05:49:35Z-
dc.identifier.urihttp://hdl.handle.net/10397/99976-
dc.language.isoenen_US
dc.publisherKeAi Communications Co.en_US
dc.rights© 2022 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.en_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer review under responsibility of Chongqing Universityen_US
dc.rightsThe following publication He, X., Li, Y., Miao, H., Xu, J., Ong, M. T.-y., Wang, C., Zheng, L., Wang, J., Huang, L., Zu, H., Yao, Z., Mi, J., Dai, B., Li, X., Yung, P. S.-h., Yuan, G., & Qin, L. (2024). High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification. Journal of Magnesium and Alloys, 12(1), 295-315 is available at https://doi.org/10.1016/j.jma.2022.12.006.en_US
dc.subjectMagnesium wireen_US
dc.subjectACL reconstructionen_US
dc.subjectMagnesium alloyen_US
dc.subjectBiomaterialsen_US
dc.subjectEndochondral ossificationen_US
dc.titleHigh formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossificationen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage295en_US
dc.identifier.epage315en_US
dc.identifier.volume12en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1016/j.jma.2022.12.006en_US
dcterms.abstractAfter reconstructing the anterior cruciate ligament (ACL), unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing stage. With good biological features and high formability, Magnesium-Zinc-Gadolinium (ZG21) wires are developed to bunch the tendon graft for matching the bone tunnel during transplantation. Microstructure, tensile strength, degradation, and cytotoxicity of ZG21 wire are evaluated. The rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT, histology, and mechanical test. The SEM/EDS, immunochemistry, and in vitro assessments are performed to investigate the underlying mechanism. Material tests demonstrate the high formability of ZG21 wire as surgical suture. Micro-CT shows ZG21 wire degradation accelerates tunnel bone formation, and histologically with earlier and more fibrocartilage regeneration at the healing interface. The mechanical test shows higher ultimate load in the ZG21 group. The SEM/EDS presents ZG21 wire degradation triggered calcium phosphate (Ca-P) deposition. IHC results demonstrate upregulation of Wnt3a, BMP2, and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of healing. In vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a, β catenin, ocn and opn to stimulate osteogenesis. Ex vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon tissue. In conclusion, the ZG21 wire is feasible for tendon graft bunching. Its degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of magnesium and alloys, Jan. 2024, v. 12, no. 1, p. 295-315en_US
dcterms.isPartOfJournal of magnesium and alloysen_US
dcterms.issued2022-01-
dc.identifier.scopus2-s2.0-85146973848-
dc.identifier.eissn2213-9567en_US
dc.description.validate202307 bcchen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOS-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextNational Natural Science Foundation of Chinaen_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryCCen_US
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