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http://hdl.handle.net/10397/95726
Title: | The non-pharmaceutical interventions may affect the advantage in transmission of mutated variants during epidemics : a conceptual model for COVID-19 | Authors: | Zhao, S Wang, K Chong, MKC Musa, SS He, M Han, L He, D Wang, MH |
Issue Date: | 7-Jun-2022 | Source: | Journal of theoretical biology, 7 June 2022, v. 542, 111105 | Abstract: | As the COVID-19 pandemic continues, genetic mutations in SARS-CoV-2 emerge, and some of them are found more contagious than the previously identified strains, acting as the major mechanism for many large-scale epidemics. The transmission advantage of mutated variants is widely believed as an innate biological feature that is difficult to be altered by artificial factors. In this study, we explore how non-pharmaceutical interventions (NPI) may affect transmission advantage. A two-strain compartmental epidemic model is proposed and simulated to investigate the biological mechanism of the relationships among different NPIs, the changes in transmissibility of each strain and transmission advantage. Although the NPIs are effective in flattening the epidemic curve, we demonstrate that NPIs probably lead to a decline in transmission advantage, which is likely to occur if the NPIs become intensive. Our findings uncover the mechanistic relationship between NPIs and transmission advantage dynamically, and highlight the important role of NPIs not only in controlling the intensity of epidemics but also in slowing or even containing the growth of the proportion of variants. | Keywords: | COVID-19 Mathematical modelling Non-pharmaceutical intervention Reproduction number Transmission advantage |
Publisher: | Academic Press | Journal: | Journal of theoretical biology | EISSN: | 0022-5193 | DOI: | 10.1016/j.jtbi.2022.111105 | Rights: | © 2022 Elsevier Ltd. All rights reserved. © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The following publication Zhao, S., Wang, K., Chong, M. K. C., Musa, S. S., He, M., Han, L., He, D., & Wang, M. H. (2022). The non-pharmaceutical interventions may affect the advantage in transmission of mutated variants during epidemics: A conceptual model for COVID-19. Journal of Theoretical Biology, 542, 111105 is available at https://dx.doi.org/10.1016/j.jtbi.2022.111105. |
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Zhao_Non-Pharmaceutical_Interventions_Transmission.pdf | Pre-Published version | 2.9 MB | Adobe PDF | View/Open |
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