Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95631
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Noonan, MAP | en_US |
dc.creator | Chau, BKH | en_US |
dc.creator | Rushworth, MFS | en_US |
dc.creator | Fellows, LK | en_US |
dc.date.accessioned | 2022-09-23T09:52:19Z | - |
dc.date.available | 2022-09-23T09:52:19Z | - |
dc.identifier.issn | 0270-6474 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/95631 | - |
dc.language.iso | en | en_US |
dc.publisher | Society for Neuroscience | en_US |
dc.rights | Copyright remains with the author | en_US |
dc.rights | This article is made available under the Creative Commons Attribution 4.0 International License (CC-BY) (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Noonan, M. P., Chau, B. K., Rushworth, M. F., & Fellows, L. K. (2017). Contrasting effects of medial and lateral orbitofrontal cortex lesions on credit assignment and decision-making in humans. Journal of Neuroscience, 37(29), 7023-7035 is available at https://doi.org/10.1523/JNEUROSCI.0692-17.2017. | en_US |
dc.subject | Credit assignment | en_US |
dc.subject | Decision-making | en_US |
dc.subject | Orbitofrontal cortex | en_US |
dc.subject | Prefrontal cortex | en_US |
dc.subject | Reward | en_US |
dc.subject | Ventromedial prefrontal cortex | en_US |
dc.title | Contrasting effects of medial and lateral orbitofrontal cortex lesions on credit assignment and decision-making in humans | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 7023 | en_US |
dc.identifier.epage | 7035 | en_US |
dc.identifier.volume | 37 | en_US |
dc.identifier.issue | 29 | en_US |
dc.identifier.doi | 10.1523/JNEUROSCI.0692-17.2017 | en_US |
dcterms.abstract | The orbitofrontal cortex is critical for goal-directed behavior. Recent work in macaques has suggested the lateral orbitofrontal cortex (lOFC) is relatively more concerned with assignment of credit for rewards to particular choices during value-guided learning, whereas the medial orbitofrontal cortex (often referred to as ventromedial prefrontal cortex in humans; vmPFC/mOFC) is involved in constraining the decision to the relevant options. We examined whether people with damage restricted to subregions of prefrontal cortex showed the patterns of impairment observed in prior investigations of the effects of lesions to homologous regions in macaques. Groups of patients with either lOFC (predominantly right hemisphere), mOFC/vmPFC, or dorsomedial prefrontal (DMF), and a comparison group of healthy age- and education-matched controls performed a probabilistic 3-choice decision-making task. We report anatomically specific patterns of impairment. We found that credit assignment, as indexed by the normal influence of contingent relationships between choice and reward, is reduced in lOFC patients compared with Controls and mOFC/vmPFC patients. Moreover, the effects of reward contingency on choice were similar for patients with lesions in DMF or mOFC/vmPFC, compared with Controls. By contrast, mOFC/vmPFC-lesioned patients made more stochastic choices than Controls when the decision was framed by valuable distracting alternatives, suggesting that value comparisons were no longer independent of irrelevant options. Once again, there was evidence of regional specialization: patients with lOFC lesions were unimpaired relative to Controls. As in macaques, human lOFC and mOFC/vmPFC are necessary for contingent learning and value-guided decision-making, respectively. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of neuroscience, 19 July 2017, v. 37, no. 29, p. 7023-7035 | en_US |
dcterms.isPartOf | Journal of neuroscience | en_US |
dcterms.issued | 2017-07-19 | - |
dc.identifier.isi | WOS:000405809700019 | - |
dc.identifier.scopus | 2-s2.0-85025132401 | - |
dc.identifier.pmid | 28630257 | - |
dc.identifier.eissn | 1529-2401 | en_US |
dc.description.validate | 202209 bckw | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | RGC-B2-1412 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Canadian Institutes of Health Research Operating Grant | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Noonan_Contrasting_Effects_Medial.pdf | 1.7 MB | Adobe PDF | View/Open |
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