Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95559
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Tse, KH | en_US |
dc.creator | Herrup, K | en_US |
dc.date.accessioned | 2022-09-21T03:06:48Z | - |
dc.date.available | 2022-09-21T03:06:48Z | - |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/95559 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | © 2017 International Society for Neurochemistry | en_US |
dc.rights | This is the peer reviewed version of the following article: Tse, K.-H. and Herrup, K. (2017), Re-imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead. J. Neurochem., 143: 432-444, which has been published in final form at https://doi.org/10.1111/jnc.14079. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Cell cycle | en_US |
dc.subject | Cell death | en_US |
dc.subject | DNA damage | en_US |
dc.subject | Myelin | en_US |
dc.title | Re-imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 432 | en_US |
dc.identifier.epage | 444 | en_US |
dc.identifier.volume | 143 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.doi | 10.1111/jnc.14079 | en_US |
dcterms.abstract | Many have criticized the amyloid cascade hypothesis of Alzheimer's disease for its inconsistencies and failures to either accurately predict disease symptoms or guide the development of productive therapies. In addition to criticisms, however, we believe that the field would benefit from having alternative narratives and disease models that can either replace or function alongside of an amyloid-centric view of Alzheimer's. This review is an attempt to meet that need. We offer three experimentally verified amyloid-independent mechanisms, each of which plausibly contributes substantially to the aetiology of Alzheimer's disease: loss of DNA integrity, faulty cell cycle regulation, regression of myelination. We outline the ways in which the failure of each can contribute to AD initiation and progression, and review how, acting alone or in combination with each other, they are sufficient for explaining the full range of AD pathologies. Yet, these three alternatives represent only a few of the many non-amyloid mechanisms that can explain AD pathogenesis. Therefore instead of proposing a single ‘alternative hypothesis’ to the amyloid cascade theory, sporadic AD is pictured as the result of independent yet intersecting age-related pathologies that afflict the ageing human brain. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of neurochemistry, Nov. 2017, v. 143, no. 4, p. 432-444 | en_US |
dcterms.isPartOf | Journal of neurochemistry | en_US |
dcterms.issued | 2017-11 | - |
dc.identifier.isi | WOS:000415368800005 | - |
dc.identifier.scopus | 2-s2.0-85021263676 | - |
dc.identifier.pmid | 28547865 | - |
dc.identifier.eissn | 1471-4159 | en_US |
dc.description.validate | 202209 bckw | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | RGC-B2-0611 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Key Basic Research Program of China | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tse_Re-imagining_Alzheimers_Disease.pdf | Pre-Published version | 2.08 MB | Adobe PDF | View/Open |
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