Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95494
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | So, CM | en_US |
dc.creator | Yuen, OY | en_US |
dc.creator | Ng, SS | en_US |
dc.creator | Chen, Z | en_US |
dc.date.accessioned | 2022-09-19T02:22:15Z | - |
dc.date.available | 2022-09-19T02:22:15Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/95494 | - |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | © 2021 American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscatal.1c02146. | en_US |
dc.subject | Chemoselectivity | en_US |
dc.subject | Palladium | en_US |
dc.subject | Phosphine | en_US |
dc.subject | Polyhalogenated aryl triflates | en_US |
dc.subject | Suzuki−Miyaura coupling | en_US |
dc.title | General chemoselective suzuki-miyaura coupling of polyhalogenated aryl triflates enabled by an alkyl-heteroaryl-based phosphine ligand | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 7820 | en_US |
dc.identifier.epage | 7827 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 13 | en_US |
dc.identifier.doi | 10.1021/acscatal.1c02146 | en_US |
dcterms.abstract | This study describes a general chemoselective Suzuki-Miyaura coupling of polyhalogenated aryl triflates with the reactivity order of C-Cl > C-OTf using a Pd/L33 catalyst. The methine hydrogen and the steric hindrance offered by the alkyl bottom ring of L33 were found to be key factors in reactivity and chemoselectivity. With the Pd/ L33 catalyst, a wide range of polyhalogenated (hetero)aryl triflates, which were independent of the substrates and of the relative positioning of the competing reaction sites, coupled well with (hetero)aryl, alkenyl, and alkylboronic acids to obtain the corresponding products with good chemoselectivity and yields. The chemoselective reaction could easily be scaled up to the gram scale, and the use of parts per million levels of Pd catalyst (as low as 10 ppm Pd) was achieved. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | ACS catalysis, 2 July 2021, v. 11, no. 13, p. 7820-7827 | en_US |
dcterms.isPartOf | ACS catalysis | en_US |
dcterms.issued | 2021-07-02 | - |
dc.identifier.scopus | 2-s2.0-85108679213 | - |
dc.identifier.eissn | 2155-5435 | en_US |
dc.description.validate | 202209_bcww | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | ABCT-0087 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; Science, Technology and Innovation Commission of Shenzhen Municipality | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 55035581 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
So_General_Chemoselective_Suzuki-Miyaura.pdf | Pre-Published version | 901.8 kB | Adobe PDF | View/Open |
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