Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94654
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Guo, J | en_US |
dc.creator | Wu, Y | en_US |
dc.creator | Gong, Z | en_US |
dc.creator | Chen, X | en_US |
dc.creator | Cao, F | en_US |
dc.creator | Kala, S | en_US |
dc.creator | Qiu, Z | en_US |
dc.creator | Zhao, X | en_US |
dc.creator | Chen, JJ | en_US |
dc.creator | He, D | en_US |
dc.creator | Chen, T | en_US |
dc.creator | Zeng, R | en_US |
dc.creator | Zhu, J | en_US |
dc.creator | Wong, KF | en_US |
dc.creator | Murugappan, S | en_US |
dc.creator | Zhu, T | en_US |
dc.creator | Xian, Q | en_US |
dc.creator | Hou, X | en_US |
dc.creator | Ruan, YC | en_US |
dc.creator | Li, B | en_US |
dc.creator | Li, YC | en_US |
dc.creator | Zhang, Y | en_US |
dc.creator | Sun, L | en_US |
dc.date.accessioned | 2022-08-25T07:11:23Z | - |
dc.date.available | 2022-08-25T07:11:23Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/94654 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Guo, J., Wu, Y., Gong, Z., Chen, X., Cao, F., Kala, S., ... & Sun, L. (2022). Photonic Nanojet‐Mediated Optogenetics. Advanced Science, 9(12), 2104140 is available at https://doi.org/10.1002/advs.202104140 | en_US |
dc.subject | Light focusing | en_US |
dc.subject | Microspheres | en_US |
dc.subject | Optogenetics | en_US |
dc.subject | Photonic nanojets | en_US |
dc.title | Photonic nanojet-mediated optogenetics | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.doi | 10.1002/advs.202104140 | en_US |
dcterms.abstract | Optogenetics has become a widely used technique in neuroscience research, capable of controlling neuronal activity with high spatiotemporal precision and cell-type specificity. Expressing exogenous opsins in the selected cells can induce neuronal activation upon light irradiation, and the activation depends on the power of incident light. However, high optical power can also lead to off-target neuronal activation or even cell damage. Limiting the incident power, but enhancing power distribution to the targeted neurons, can improve optogenetic efficiency and reduce off-target effects. Here, the use of optical lenses made of polystyrene microspheres is demonstrated to achieve effective focusing of the incident light of relatively low power to neighboring neurons via photonic jets. The presence of microspheres significantly localizes and enhances the power density to the target neurons both in vitro and ex vivo, resulting in increased inward current and evoked action potentials. In vivo results show optogenetic stimulation with microspheres that can evoke significantly more motor behavior and neuronal activation at lowered power density. In all, a proof-of-concept of a strategy is demonstrated to increase the efficacy of optogenetic neuromodulation using pulses of reduced optical power. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 25 Apr. 2022, v. 9, no. 12, 2104140 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2022-04-25 | - |
dc.identifier.isi | WOS:000758089000001 | - |
dc.identifier.scopus | 2-s2.0-85124877217 | - |
dc.identifier.pmid | 35187865 | - |
dc.identifier.artn | 2104140 | en_US |
dc.description.validate | 202208 bckw | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a1631 | - |
dc.identifier.SubFormID | 45664 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Photonic_Nanojet-mediated_Optogenetics.pdf | 2.46 MB | Adobe PDF | View/Open |
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