Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94423
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.contributor | Mainland Development Office | en_US |
dc.creator | Zhong, T | en_US |
dc.creator | Qiu, Z | en_US |
dc.creator | Wu, Y | en_US |
dc.creator | Guo, J | en_US |
dc.creator | Li, H | en_US |
dc.creator | Yu, Z | en_US |
dc.creator | Cheng, S | en_US |
dc.creator | Zhou, Y | en_US |
dc.creator | Zhu, J | en_US |
dc.creator | Tian, J | en_US |
dc.creator | Sun, L | en_US |
dc.creator | Lai, P | en_US |
dc.date.accessioned | 2022-08-16T07:50:42Z | - |
dc.date.available | 2022-08-16T07:50:42Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/94423 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA | en_US |
dc.rights | © 2021 The Authors. Advanced Photonics Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Zhong, T., Qiu, Z., Wu, Y., Guo, J., Li, H., Yu, Z., ... & Lai, P. (2022). Optically Selective Neuron Stimulation with a Wavefront Shaping‐Empowered Multimode Fiber. Advanced Photonics Research, 3(3), 2100231 is available at https://doi.org/10.1002/adpr.202100231 | en_US |
dc.subject | Multimode fibers | en_US |
dc.subject | Neuron stimulations | en_US |
dc.subject | Optogenetics | en_US |
dc.subject | Transmission matrices | en_US |
dc.subject | Wavefront shaping | en_US |
dc.title | Optically selective neuron stimulation with a wavefront shaping-empowered multimode fiber | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.1002/adpr.202100231 | en_US |
dcterms.abstract | Optogenetics is proved to be a powerful tool for exploring the connection between behavior and neural circuits. The progress greatly benefits from the advances of optical techniques that enable high spatiotemporal resolution for selective single-neuron stimulation through modulating light. Efficient propagation of modulated light, however, is handicapped by strong optical scattering in biological tissues, which results in inherent tradeoff between penetration depth and resolution. Schemes like graded index (GRIN) lens-based microendoscopes are developed to yield more confined delivery of light, but tissue damage caused by the insertion of the bulky components cannot be ignored. Herein, an optically selective precise neuron stimulation using an ultrathin multimode fiber (MMF) is demonstrated, which is empowered by optical wavefront shaping to achieve light focusing and rapid raster scanning without mechanical movement at the distal end of the MMF and even through a mouse skull. With this method, primary neurons expressing Chr2 can be regulated spatiotemporally in experiment. Although a lot shall be further improved, the work may open up new venues for noninvasive or minimally invasive all-optical investigation of neural circuits in used-to-be optically inaccessible brain regions. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced photonics research, Mar. 2022, v. 3, no. 3, 2100231 | en_US |
dcterms.isPartOf | Advanced photonics research | en_US |
dcterms.issued | 2022-03 | - |
dc.identifier.eissn | 2699-9293 | en_US |
dc.identifier.artn | 2100231 | en_US |
dc.description.validate | 202208 bckw | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a1564, a1631 | - |
dc.identifier.SubFormID | 45438, 45667 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; Guangdong Science and Technology Commission; Hong Kong Innovation and Technology Commission; Shenzhen Science and Technology Innovation Commission | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Zhong_Optically_Selective_Neuron.pdf | 1.63 MB | Adobe PDF | View/Open |
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