Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94357
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Wong, WK | en_US |
dc.creator | Yin, B | en_US |
dc.creator | Rakhmatullina, A | en_US |
dc.creator | Zhou, J | en_US |
dc.creator | Wong, SHD | en_US |
dc.date.accessioned | 2022-08-12T03:04:31Z | - |
dc.date.available | 2022-08-12T03:04:31Z | - |
dc.identifier.issn | 2666-1381 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/94357 | - |
dc.language.iso | en | en_US |
dc.publisher | Ke Ai Publishing Communications Ltd. | en_US |
dc.rights | © 2021 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | en_US |
dc.rights | The following publication Wong, W. K., Yin, B., Rakhmatullina, A., Zhou, J., & Wong, S. H. D. (2021). Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy. Engineered Regeneration, 2, 70-81 is available at https://doi.org/10.1016/j.engreg.2021.06.001. | en_US |
dc.subject | Adoptive T-cell immunotherapyT- | en_US |
dc.subject | Dynamic nanobiomaterials | en_US |
dc.subject | Ligand presentation | en_US |
dc.subject | T-cell mechanobiology | en_US |
dc.title | Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 70 | en_US |
dc.identifier.epage | 81 | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.doi | 10.1016/j.engreg.2021.06.001 | en_US |
dcterms.abstract | Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor. The outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells, which provides signals for generating different T-cell phenotypes with different roles in tumor removal. However, such interaction is often not optimal in vivo and results in low therapeutic efficacy. To reach the full potential of the T-cell response, current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell fate. In this perspective, we provide (1) an overview of ACT and general T-cells behaviors, (2) explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors, (3) and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Engineered Regeneration, 2021, v. 2, p. 70-81 | en_US |
dcterms.isPartOf | Engineered regeneration | en_US |
dcterms.issued | 2021 | - |
dc.identifier.scopus | 2-s2.0-85117833198 | - |
dc.description.validate | 202208 bcfc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | BME-0023 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | The Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 53364909 | - |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S2666138121000050-main.pdf | 2.56 MB | Adobe PDF | View/Open |
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