Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94356
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Au, MT | en_US |
dc.creator | Shi, J | en_US |
dc.creator | Fan, Y | en_US |
dc.creator | Ni, J | en_US |
dc.creator | Wen, C | en_US |
dc.creator | Yang, M | en_US |
dc.date.accessioned | 2022-08-12T03:04:30Z | - |
dc.date.available | 2022-08-12T03:04:30Z | - |
dc.identifier.issn | 1936-0851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/94356 | - |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | © 2021 American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Acs Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.1c02454. | en_US |
dc.subject | Gold nanorods | en_US |
dc.subject | Molybdenum disulfide | en_US |
dc.subject | Nerve growth factor | en_US |
dc.subject | Osteoarthritis | en_US |
dc.subject | Pain relief | en_US |
dc.subject | Theranostics | en_US |
dc.title | Nerve growth factor-targeted molecular theranostics based on molybdenum disulfide nanosheet-coated gold nanorods (MoS2-AuNR) for osteoarthritis pain | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 11711 | en_US |
dc.identifier.epage | 11723 | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.doi | 10.1021/acsnano.1c02454 | en_US |
dcterms.abstract | Osteoarthritis (OA) is a leading cause of chronic pain in the elderly worldwide. Yet current diagnosis and therapy for OA pain are subjective and nonspecific with significant adverse effects. Here, we introduced a theranostic nanoprobe based on molybdenum disulfide nanosheet-coated gold nanorods (MoS2-AuNR) targeting never growth factor (NGF), a key player in pain sensation, for photoacoustic pain imaging and near-infrared (NIR) imaging-guided photothermal analgesic therapy. MoS2 coating significantly improved the photoacoustic and photothermal performance of AuNR. Functionalization of MoS2-AuNR nanoprobes by conjugating with NGF antibody enabled active targeting on painful OA knees in a surgical OA murine model. We observed that our functional nanoprobes accumulated in the OA knee rather than the contralateral intact one, and the amount was correlated with the severity of mechanical allodynia in our mouse model. Under imaging guidance, NIR-excited photothermal therapy could mitigate mechanical allodynia and walking imbalance behavior for both subacute and chronic stages of OA in a preclinical setting. This molecular theranostic approach enabled us to specifically localize the source of OA pain and efficiently block peripheral pain transmission. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | ACS nano, 27 July 2021, v. 15, no. 7, p. 11711-11723 | en_US |
dcterms.isPartOf | ACS nano | en_US |
dcterms.issued | 2021-07-27 | - |
dc.identifier.scopus | 2-s2.0-85110994878 | - |
dc.identifier.eissn | 1936-086X | en_US |
dc.description.validate | 202208 bcfc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | BME-0014 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Health and Medical Research Fund Scheme; Hong Kong Research Grants Council; NSFC; Hong Hong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 54917744 | - |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Au_Nerve_Growth_Factor-Targeted.pdf | Pre-Published version | 2.59 MB | Adobe PDF | View/Open |
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