Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/92019
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dc.contributorDepartment of Biomedical Engineering-
dc.creatorDou, Y-
dc.creatorSun, X-
dc.creatorMa, X-
dc.creatorZhao, X-
dc.creatorYang, Q-
dc.date.accessioned2022-02-07T07:05:02Z-
dc.date.available2022-02-07T07:05:02Z-
dc.identifier.urihttp://hdl.handle.net/10397/92019-
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.rights© 2021 Dou, Sun, Ma, Zhao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Dou Y, Sun X, Ma X, Zhao X and Yang Q (2021) Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies. Front. Bioeng. Biotechnol. 9:592118 is available at https://doi.org/10.3389/fbioe.2021.592118en_US
dc.subjectDisk herniationen_US
dc.subjectIntervertebral disk degenerationen_US
dc.subjectLow back painen_US
dc.subjectMicroenvironmenten_US
dc.subjectRegenerationen_US
dc.subjectScaffolden_US
dc.subjectTissue engineeringen_US
dc.titleIntervertebral disk degeneration : the microenvironment and tissue engineering strategiesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume9-
dc.identifier.doi10.3389/fbioe.2021.592118-
dcterms.abstractIntervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the intervertebral disk (IVD). Tissue engineering is a promising strategy for IVDD due to its ability to restore a healthy microenvironment and promote IVD regeneration. This review briefly summarizes the IVD anatomy and composition and then sets out elements of the microenvironment and the interactions. We rationalized different scaffolds based on tissue engineering strategies used recently. To fulfill the complete restoration of a healthy IVD microenvironment, we propose that various tissue engineering strategies should be combined and customized to create personalized therapeutic strategies for each individual.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationFrontiers in bioengineering and biotechnology, July 2021, v. 9, 592118-
dcterms.isPartOfFrontiers in bioengineering and biotechnology-
dcterms.issued2021-07-
dc.identifier.eissn2296-4185-
dc.identifier.artn592118-
dc.description.validate202202 bcvc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextThis study was supported by the National Key R&D Program of China (2020YFC1107402), National Natural Science Foundation of China (81871782, 31900968, and 81871777), and Tianjin Science Fund for Distinguished Young Scholars (18JCJQJC47900). Research Foundation of the Tianjin Health Commision (KJ20052).en_US
dc.description.pubStatusPublisheden_US
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