Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91998
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLi, B-
dc.creatorZhao, Y-
dc.date.accessioned2022-02-07T07:04:54Z-
dc.date.available2022-02-07T07:04:54Z-
dc.identifier.urihttp://hdl.handle.net/10397/91998-
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.rights© 2021 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)en_US
dc.rightsThe following publication Li, B.; Zhao, Y. Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities. Pathogens 2021, 10, 967 is available at https://doi.org/10.3390/pathogens10080967en_US
dc.subjectAntigenic variationen_US
dc.subjectDNA binding activityen_US
dc.subjectMyb domainen_US
dc.subjectRAP1en_US
dc.subjectTelomereen_US
dc.subjectTRFen_US
dc.subjectTrypanosoma bruceien_US
dc.subjectVSGen_US
dc.titleRegulation of antigenic variation by trypanosoma brucei telomere proteins depends on their unique DNA binding activitiesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume10-
dc.identifier.issue8-
dc.identifier.doi10.3390/pathogens10080967-
dcterms.abstractTrypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere proteins with unique nucleic acid binding activities, and summarize their functions in telomere integrity and stability, VSG switching, and monoallelic VSG expression. Targeting the unique features of TbTRF and TbRAP1′ s nucleic acid binding activities to perturb the integrity of telomere structure and disrupt VSG monoallelic expression may serve as potential therapeutic strategy against T. brucei.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPathogens, Aug. 2021, v. 10, no. 8, 967-
dcterms.isPartOfPathogens-
dcterms.issued2021-08-
dc.identifier.eissn2076-0817-
dc.identifier.artn967-
dc.description.validate202202 bcvc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextThis work is supported by NIH, AI066095 (PI, B.L.), Research Grants Council Hong Kong, PolyU 151062/18M (PI, Y.Z.), and Shenzhen Basic Research Program, JCYJ20170818104619974 (PI, Y.Z.).en_US
dc.description.pubStatusPublisheden_US
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