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Title: A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders : a systematic review and meta-analysis
Authors: Fu, J
Tan, S 
Peng, C
Zhou, H
Wei, S
Issue Date: Nov-2021
Source: Advances in ophthalmology practice and research, Nov. 2021, v. 1, no. 1, 100007
Abstract: Background: To evaluate the feature of different retinal layer segmentation in neuromyelitis optica spectrum disorders (NMOSD) with spectral-domain optical coherence tomography (SD-OCT) and to compare it with that in multiple sclerosis (MS), healthy controls (HC), and idiopathic optic neuritis (ION).
Methods: We retrieved four electronic atabases, including Pubmed, Embase, Cochrane Library, and Web of Science from inception to September 1st, 2021. A meta-analysis was performed to compare different retinal layer segmentation thicknesses between patients with or without a history of optic neuritis (ON) in NMOSD and the control group, including patients with MS, HC, and ION.
Results: Forty-two studies were included and the interval between the last ON onset and examination was greater than 3 months. Compared with that in HC eyes, the loss of retinal nerve fiber layer (RNFL) and macular ganglion cell and inner plexiform layer (GC-IPL) was serious in NMOSD eye especially after ON. Moreover, compared with that in ION eyes or MS-related-ON eyes, the injury to the peripapillary retinal nerve fiber layer (pRNFL) was severe in NMOSD-related-ON eyes. In addition, the correlation coefficient between pRNFL and prognostic visual acuity was 0.43. However, the one-arm study revealed the inner nuclear layer (INL) was thickened in NMOSDrelated-ON eyes compared with HC eyes.
Conclusions: Inclusion of the RNFL and macular GC-IPL is recommended for monitoring disease progression and attention should be paid to changes in the INL.
Keywords: Neuromyelitis optica spectrum disorders
Spectral-domain optical coherence tomography
Multiple sclerosis
Idiopathic optic neuritis
Retinal nerve fiber layer
Publisher: Elsevier Inc.
Journal: Advances in ophthalmology practice and research 
ISSN: 2667-3762
DOI: 10.1016/j.aopr.2021.100007
Rights: © 2021 The Author(s). Published by Elsevier Inc. on behalf of Zhejiang University Press. This is an open access article under the CC BY-NC-ND license (
The following publication Fu, J., Tan, S., Peng, C., Zhou, H., & Wei, S. (2021). A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis. Advances in Ophthalmology Practice and Research, 1, 100007 is available at
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