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| Title: | A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders : a systematic review and meta-analysis | Authors: | Fu, J Tan, S Peng, C Zhou, H Wei, S |
Issue Date: | Nov-2021 | Source: | Advances in ophthalmology practice and research, Nov. 2021, v. 1, no. 1, 100007 | Abstract: | Background: To evaluate the feature of different retinal layer segmentation in neuromyelitis optica spectrum disorders (NMOSD) with spectral-domain optical coherence tomography (SD-OCT) and to compare it with that in
multiple sclerosis (MS), healthy controls (HC), and idiopathic optic neuritis (ION). Methods: We retrieved four electronic atabases, including Pubmed, Embase, Cochrane Library, and Web of Science from inception to September 1st, 2021. A meta-analysis was performed to compare different retinal layer segmentation thicknesses between patients with or without a history of optic neuritis (ON) in NMOSD and the control group, including patients with MS, HC, and ION. Results: Forty-two studies were included and the interval between the last ON onset and examination was greater than 3 months. Compared with that in HC eyes, the loss of retinal nerve fiber layer (RNFL) and macular ganglion cell and inner plexiform layer (GC-IPL) was serious in NMOSD eye especially after ON. Moreover, compared with that in ION eyes or MS-related-ON eyes, the injury to the peripapillary retinal nerve fiber layer (pRNFL) was severe in NMOSD-related-ON eyes. In addition, the correlation coefficient between pRNFL and prognostic visual acuity was 0.43. However, the one-arm study revealed the inner nuclear layer (INL) was thickened in NMOSDrelated-ON eyes compared with HC eyes. Conclusions: Inclusion of the RNFL and macular GC-IPL is recommended for monitoring disease progression and attention should be paid to changes in the INL. |
Keywords: | Neuromyelitis optica spectrum disorders Spectral-domain optical coherence tomography Multiple sclerosis Idiopathic optic neuritis Retinal nerve fiber layer |
Publisher: | Elsevier Inc. | Journal: | Advances in ophthalmology practice and research | ISSN: | 2667-3762 | DOI: | 10.1016/j.aopr.2021.100007 | Rights: | © 2021 The Author(s). Published by Elsevier Inc. on behalf of Zhejiang University Press. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Fu, J., Tan, S., Peng, C., Zhou, H., & Wei, S. (2021). A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis. Advances in Ophthalmology Practice and Research, 1, 100007 is available at https://doi.org/10.1016/j.aopr.2021.100007 |
| Appears in Collections: | Journal/Magazine Article |
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| FU_Comparative_Study_Alteration.pdf | 1.22 MB | Adobe PDF | View/Open |
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