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Title: Attitudes toward COVID-19 vaccines in Chinese adolescents
Authors: Cai, H
Bai, W
Liu, S
Liu, HZ
Chen, X
Qi, H
Liu, R
Cheung, T 
Su, ZH
Ng, CH
Xiang, YT
Issue Date: Jul-2021
Source: Frontiers in medicine, July 2021, v. 8, 691079
Abstract: Background: As COVID-19 vaccination programs are being implemented widely, it is important to examine the attitudes of adolescents toward the COVID-19 vaccine and its uptake. The aim of this study was to examine the acceptance of and attitudes toward COVID-19 vaccines, and their associated factors among adolescents in China.
Methods: This was a cross-sectional, observational study conducted between November 27, 2020 and March 12, 2021 using snowball sampling method. Basic sociodemographic characteristics, health-related information, severity of depressive and anxiety symptoms, and attitudes and behavior toward COVID-19 vaccines were assessed.
Results: Overall, 1,057 adolescents participated in this study, yielding a response rate of 89.3%. There were 799 (75.59%) [95% Confidence Interval (CI) 73.00-78.18%] adolescents who would accept future COVID-19 vaccination. Binary logistic regression analysis revealed that adolescents who previously heard about COVID-19 vaccines (P = 0.001, odds ratio (OR) = 1.90, 95%CI:1.32-2.74), who thought that COVID-19 vaccines could protect them from COVID-19 infection (P = 0.002, OR = 2.93, 95%CI: 1.49-5.70), and those who encouraged their family members and friends to get vaccinated (P < 0.001, OR = 12.19, 95%CI: 6.78-21.92) and who believed that vaccines are safe (P = 0.012, OR = 3.94, 95%CI: 1.36-11.44) were more likely to accept future COVID-19 vaccination. In addition, younger adolescents (P = 0.003, OR = 0.93, 95%CI: 0.89-0.98) were more likely to accept future COVID-19 vaccines than older adolescents.
Conclusions: In conclusion, Chinese adolescents appeared to have positive attitudes toward COVID-19 vaccines. It is important to increase public confidence and knowledge regarding the efficacy and safety of COVID-19 vaccines to maximize the success of vaccination programs.
Keywords: COVID-19 vaccines
Attitude toward vaccines
Efficacy and safety of COVID-19 vaccines
Acceptance of COVID-19 vaccines
Publisher: Frontiers Research Foundation
Journal: Frontiers in medicine 
EISSN: 2296-858X
DOI: 10.3389/fmed.2021.691079
Rights: Copyright © 2021 Cai, Bai, Liu, Liu, Chen, Qi, Liu, Cheung, Su, Ng and Xiang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Cai H, Bai W, Liu S, Liu H, Chen X, Qi H, Liu R, Cheung T, Su Z, Ng CH and Xiang Y-T (2021) Attitudes Toward COVID-19 Vaccines in Chinese Adolescents. Front. Med. 8:691079 is available at
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