Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91674
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | en_US |
dc.contributor | University Research Facility in Life Sciences | en_US |
dc.creator | Chow, HM | en_US |
dc.creator | Sun, JKL | en_US |
dc.creator | Hart, RP | en_US |
dc.creator | Cheng, KKY | en_US |
dc.creator | Hung, CHL | en_US |
dc.creator | Lau, TM | en_US |
dc.creator | Kwan, KM | en_US |
dc.date.accessioned | 2021-11-24T06:07:36Z | - |
dc.date.available | 2021-11-24T06:07:36Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/91674 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2021 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Ain Shams University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Chow, H.-M., Sun, J. K.-L., Hart, R. P., Cheng, K. K.-Y., Hung, C. H. L., Lau, T.-M., Kwan, K.-M., Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Adv. Sci. 2021, 8, 2004993 is available at https://doi.org/10.1002/advs.202004993 | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Amino acid metabolism | en_US |
dc.subject | Astrocyte | en_US |
dc.subject | Metabolic reprogramming | en_US |
dc.subject | Wnt signaling | en_US |
dc.title | Low-density lipoprotein receptor-related protein 6 cell surface availability regulates fuel metabolism in astrocytes | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 16 | en_US |
dc.identifier.doi | 10.1002/advs.202004993 | en_US |
dcterms.abstract | Early changes in astrocyte energy metabolism are associated with late-onset Alzheimer's disease (LOAD), but the underlying mechanism remains elusive. A previous study suggested an association between a synonymous SNP (rs1012672, C -> T) in LRP6 gene and LOAD; and that is indeed correlated with diminished LRP6 gene expression in the frontal cortex region. The authors show that LRP6 is a unique Wnt coreceptor on astrocytes, serving as a bimodal switch that modulates their metabolic landscapes. The Wnt-LRP6 mediated mTOR-AKT axis is essential for sustaining glucose metabolism. In its absence, Wnt switches to activate the LRP6-independent Ca2+-PKC-NFAT axis, resulting in a transcription network that favors glutamine and branched chain amino acids (BCAAs) catabolism over glucose metabolism. Exhaustion of these raw materials essential for neurotransmitter biosynthesis and recycling results in compromised synaptic, cognitive, and memory functions; priming for early changes that are frequently found in LOAD. The authors also highlight that intranasal supplementation of glutamine and BCAAs is effective in preserving neuronal integrity and brain functions, proposing a nutrient-based method for delaying cognitive and memory decline when LRP6 cell surface levels and functions are suboptimal. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 18 Aug. 2021, v. 8, no. 16, 2004993 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2021-08 | - |
dc.identifier.isi | WOS:000667111300001 | - |
dc.identifier.pmid | 34180138 | - |
dc.identifier.artn | 2004993 | en_US |
dc.description.validate | 202111 bchy | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Chow_Low-Density_Lipoprotein_Receptor-Related.pdf | 8.96 MB | Adobe PDF | View/Open |
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