Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91656
| Title: | pH-triggered Poly(ethylene glycol)-Poly(lactic acid/glycolic acid)/croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy | Authors: | Li, SY Lui, KH Li, X Fang, XY Lo, WS Gu, YJ Wong, WT |
Issue Date: | 2021 | Source: | ACS applied bio materials, 2021, v. 4, no. 5, p. 4152-4164 | Abstract: | The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment. | Keywords: | Multiplexed photoacoustic imaging Spectra unmixing PEG-PLGA nanoparticles Photothermal therapy Orthotopic xenograft model |
Publisher: | American Chemical Society | Journal: | ACS applied bio materials | EISSN: | 2576-6422 | DOI: | 10.1021/acsabm.0c01578 | Rights: | © 2021 The Authors. Published by American Chemical Society This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) The following publication Li, S., Lui, K. H., Li, X., Fang, X., Lo, W. S., Gu, Y. J., & Wong, W. T. (2021). pH-Triggered Poly (ethylene glycol)–Poly (lactic acid/glycolic acid)/Croconaine Nanoparticles-Assisted Multiplexed Photoacoustic Imaging and Enhanced Photothermal Cancer Therapy. ACS Applied Bio Materials, 4(5), 4152-4164 is available at https://doi.org/10.1021/acsabm.0c01578 |
| Appears in Collections: | Journal/Magazine Article |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Li_Multiplexed_Photoacoustic_Imaging.pdf | 14.64 MB | Adobe PDF | View/Open |
Access
View full-text via PolyU eLinks 
Page views
35
Last Week
0
0
Last month
Citations as of Jun 4, 2023
Downloads
39
Citations as of Jun 4, 2023
SCOPUSTM
Citations
13
Citations as of Jun 2, 2023
WEB OF SCIENCETM
Citations
12
Citations as of Jun 1, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.