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Title: Reinfection or reactivation of severe acute respiratory syndrome coronavirus 2 : a systematic review
Authors: Tang, X
Musa, SS 
Zhao, S
He, D 
Issue Date: Jun-2021
Source: Frontiers in public health, June 2021, v. 9, 663045
Abstract: As the pandemic continues, individuals with re-detectable positive (RP) SARS-CoV-2 viral RNA among recovered COVID-19 patients have raised public health concerns. It is imperative to investigate whether the cases with re-detectable positive (RP) SARS-CoV-2 might cause severe infection to the vulnerable population. In this work, we conducted a systematic review of recent literature to investigate reactivation and reinfection among the discharged COVID-19 patients that are found positive again. Our study, consisting more than a total of 113,715 patients, indicates that the RP-SARS-CoV-2 scenario occurs plausibly due to reactivation, reinfection, viral shedding, or testing errors. Nonetheless, we observe that previously infected individuals have significantly lower risk of being infected for the second time, indicating that reactivation or reinfection of SARS-CoV-2 likely have relatively less impact in the general population than the primary infection.
Keywords: COVID-19
Re-detectable positive
Publisher: Frontiers Research Foundation
Journal: Frontiers in public health 
ISSN: 2296-2565
DOI: 10.3389/fpubh.2021.663045
Rights: © 2021 Tang, Musa, Zhao and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Tang X, Musa SS, Zhao S and He D (2021) Reinfection or Reactivation of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. Front. Public Health 9:663045 is available at
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