Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91466
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Social Sciences | - |
dc.creator | Chung, JYF | - |
dc.creator | Chan, MKK | - |
dc.creator | Li, JSF | - |
dc.creator | Chan, ASW | - |
dc.creator | Tang, PCT | - |
dc.creator | Leung, KT | - |
dc.creator | To, KF | - |
dc.creator | Lan, HY | - |
dc.creator | Tang, PMK | - |
dc.date.accessioned | 2021-11-03T06:53:54Z | - |
dc.date.available | 2021-11-03T06:53:54Z | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10397/91466 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | en_US |
dc.rights | The following publication Chung, J.Y.-F.; Chan, M.K.-K.; Li, J.S.-F.; Chan, A.S.-W.; Tang, P.C.-T.; Leung, K.-T.; To, K.-F.; Lan, H.-Y.; Tang, P.M.-K. TGF- Signaling: From Tissue Fibrosis to Tumor Microenvironment. Int. J. Mol. Sci. 2021, 22, 7575 is available at https://doi.org/10.3390/ijms22147575 | en_US |
dc.subject | Fibrosis | en_US |
dc.subject | TGF-β | en_US |
dc.subject | Tumor microenvironment | en_US |
dc.title | Tgf-β signaling : from tissue fibrosis to tumor microenvironment | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 14 | - |
dc.identifier.doi | 10.3390/ijms22147575 | - |
dcterms.abstract | Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting immunoregulation via controlling the activation, proliferation, and apoptosis of immunocytes. In cancer, it plays a critical role in tumor microenvironment (TME) for accelerating invasion, metastasis, angiogenesis, and immunosuppression. Increasing evidence suggest a pleiotropic nature of TGF-β signaling as a critical pathway for generating fibrotic TME, which contains numerous cancer-associated fibroblasts (CAFs), extracellular matrix proteins, and remodeling enzymes. Its pathogenic roles and working mechanisms in tumorigenesis are still largely unclear. Importantly, recent studies successfully demonstrated the clinical implications of fibrotic TME in cancer. This review systematically summarized the latest updates and discoveries of TGF-β signaling in the fibrotic TME. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of molecular sciences, July 2021, v. 22, no. 14, 7575 | - |
dcterms.isPartOf | International journal of molecular sciences | - |
dcterms.issued | 2021-07 | - |
dc.identifier.scopus | 2-s2.0-85110498859 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.artn | 7575 | - |
dc.description.validate | 202110 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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ijms-22-07575-v2.pdf | 16.22 MB | Adobe PDF | View/Open |
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