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Title: Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations
Authors: Fu, WC 
Macqueen, PM
Jamison, TF
Issue Date: Jul-2021
Source: Chemical society reviews, 07 July 2021, v. 50, no. 13, p. 7378-7394
Abstract: Large quantities of fluorinated gases are generated as intermediates or byproducts from fluorinated polymer production annually, and they are effective ozone depleting substances or greenhouse gases. On the other hand, the incorporation of fluoroalkyl groups into drug molecules or bioactive compounds has been shown to enhance biological properties such as the bioavailability, binding selectivity, and metabolic stability. Extraction of fluoroalkyl sources, including trifluoromethyl and difluoromethyl groups, from the fluorinated gases is highly desirable, yet challenging under regular batch reaction conditions. Flow chemistry is an emerging and promising technique to address long-standing challenges in gas-liquid batch reactions such as insufficient interfacial contact and scalability issues. In this review, we highlight recent advances in continuous flow strategies toward enabling the use of fluorinated greenhouse gases in organic synthesis.
Publisher: Royal Society of Chemistry
Journal: Chemical society reviews 
ISSN: 0306-0012
EISSN: 1460-4744
DOI: 10.1039/d0cs00670j
Rights: This journal is © The Royal Society of Chemistry 2021
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (
The following publication Fu, W. C., MacQueen, P. M., & Jamison, T. F. (2021). Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations. Chemical Society Reviews is available at
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